Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape Mutants
Memory SARS-CoV-2-specific CD8<sup>+</sup> T cell responses induced upon infection or COVID-19 vaccination have been important for protecting against severe COVID-19 disease while being largely robust against variants of concern (VOCs) observed so far. However, T cell immunity may be wea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/4/542 |
| _version_ | 1797443317013676032 |
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| author | Syed Faraz Ahmed Muhammad Saqib Sohail Ahmed Abdul Quadeer Matthew R. McKay |
| author_facet | Syed Faraz Ahmed Muhammad Saqib Sohail Ahmed Abdul Quadeer Matthew R. McKay |
| author_sort | Syed Faraz Ahmed |
| collection | DOAJ |
| description | Memory SARS-CoV-2-specific CD8<sup>+</sup> T cell responses induced upon infection or COVID-19 vaccination have been important for protecting against severe COVID-19 disease while being largely robust against variants of concern (VOCs) observed so far. However, T cell immunity may be weakened by genetic mutations in future SARS-CoV-2 variants that lead to widespread T cell escape. The capacity for SARS-CoV-2 mutations to escape memory T cell responses requires comprehensive experimental investigation, though this is prohibited by the large number of SARS-CoV-2 mutations that have been observed. To guide targeted experimental studies, here we provide a screened list of potential SARS-CoV-2 T cell escape mutants. These mutants are identified as candidates for T cell escape as they lie within CD8<sup>+</sup> T cell epitopes that are commonly targeted in individuals and are predicted to abrogate HLA–peptide binding. |
| first_indexed | 2024-03-09T12:54:14Z |
| format | Article |
| id | doaj.art-b8a9d3410b08473b9aa484af0e627151 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:54:14Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b8a9d3410b08473b9aa484af0e6271512023-11-30T22:02:05ZengMDPI AGVaccines2076-393X2022-03-0110454210.3390/vaccines10040542Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape MutantsSyed Faraz Ahmed0Muhammad Saqib Sohail1Ahmed Abdul Quadeer2Matthew R. McKay3Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, ChinaDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, ChinaDepartment of Electrical and Electronic Engineering, University of Melbourne, Parkville, VIC 3010, AustraliaMemory SARS-CoV-2-specific CD8<sup>+</sup> T cell responses induced upon infection or COVID-19 vaccination have been important for protecting against severe COVID-19 disease while being largely robust against variants of concern (VOCs) observed so far. However, T cell immunity may be weakened by genetic mutations in future SARS-CoV-2 variants that lead to widespread T cell escape. The capacity for SARS-CoV-2 mutations to escape memory T cell responses requires comprehensive experimental investigation, though this is prohibited by the large number of SARS-CoV-2 mutations that have been observed. To guide targeted experimental studies, here we provide a screened list of potential SARS-CoV-2 T cell escape mutants. These mutants are identified as candidates for T cell escape as they lie within CD8<sup>+</sup> T cell epitopes that are commonly targeted in individuals and are predicted to abrogate HLA–peptide binding.https://www.mdpi.com/2076-393X/10/4/542SARS-CoV-2COVID-19CD8<sup>+</sup> T cell epitopesimmunoprevalentimmune escapemutations |
| spellingShingle | Syed Faraz Ahmed Muhammad Saqib Sohail Ahmed Abdul Quadeer Matthew R. McKay Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape Mutants Vaccines SARS-CoV-2 COVID-19 CD8<sup>+</sup> T cell epitopes immunoprevalent immune escape mutations |
| title | Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape Mutants |
| title_full | Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape Mutants |
| title_fullStr | Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape Mutants |
| title_full_unstemmed | Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape Mutants |
| title_short | Identification of Potential SARS-CoV-2 CD8<sup>+</sup> T Cell Escape Mutants |
| title_sort | identification of potential sars cov 2 cd8 sup sup t cell escape mutants |
| topic | SARS-CoV-2 COVID-19 CD8<sup>+</sup> T cell epitopes immunoprevalent immune escape mutations |
| url | https://www.mdpi.com/2076-393X/10/4/542 |
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