A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation

Digital pathology analysis using deep learning has been the subject of several studies. As with other medical data, pathological data are not easily obtained. Because deep learning-based image analysis requires large amounts of data, augmentation techniques are used to increase the size of pathologi...

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Main Authors: Juwon Kweon, Jisang Yoo, Seungjong Kim, Jaesik Won, Soonchul Kwon
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Sensors
Subjects:
Online Access:https://www.mdpi.com/1424-8220/22/10/3960
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author Juwon Kweon
Jisang Yoo
Seungjong Kim
Jaesik Won
Soonchul Kwon
author_facet Juwon Kweon
Jisang Yoo
Seungjong Kim
Jaesik Won
Soonchul Kwon
author_sort Juwon Kweon
collection DOAJ
description Digital pathology analysis using deep learning has been the subject of several studies. As with other medical data, pathological data are not easily obtained. Because deep learning-based image analysis requires large amounts of data, augmentation techniques are used to increase the size of pathological datasets. This study proposes a novel method for synthesizing brain tumor pathology data using a generative model. For image synthesis, we used embedding features extracted from a segmentation module in a general generative model. We also introduce a simple solution for training a segmentation model in an environment in which the masked label of the training dataset is not supplied. As a result of this experiment, the proposed method did not make great progress in quantitative metrics but showed improved results in the confusion rate of more than 70 subjects and the quality of the visual output.
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spelling doaj.art-b8aa6adfc3f34a1b8add00b3ea637bd02023-11-23T13:04:11ZengMDPI AGSensors1424-82202022-05-012210396010.3390/s22103960A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image GenerationJuwon Kweon0Jisang Yoo1Seungjong Kim2Jaesik Won3Soonchul Kwon4Department of Electronic Engineering, Kwangwoon University, Seoul 01897, KoreaDepartment of Electronic Engineering, Kwangwoon University, Seoul 01897, KoreaMolpaxbio, Daejeon 34047, KoreaMolpaxbio, Daejeon 34047, KoreaGraduate School of Smart Convergence, Kwangwoon University, Seoul 01897, KoreaDigital pathology analysis using deep learning has been the subject of several studies. As with other medical data, pathological data are not easily obtained. Because deep learning-based image analysis requires large amounts of data, augmentation techniques are used to increase the size of pathological datasets. This study proposes a novel method for synthesizing brain tumor pathology data using a generative model. For image synthesis, we used embedding features extracted from a segmentation module in a general generative model. We also introduce a simple solution for training a segmentation model in an environment in which the masked label of the training dataset is not supplied. As a result of this experiment, the proposed method did not make great progress in quantitative metrics but showed improved results in the confusion rate of more than 70 subjects and the quality of the visual output.https://www.mdpi.com/1424-8220/22/10/3960generative adversarial networkspathology image synthesisdigital pathology
spellingShingle Juwon Kweon
Jisang Yoo
Seungjong Kim
Jaesik Won
Soonchul Kwon
A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation
Sensors
generative adversarial networks
pathology image synthesis
digital pathology
title A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation
title_full A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation
title_fullStr A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation
title_full_unstemmed A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation
title_short A Novel Method Based on GAN Using a Segmentation Module for Oligodendroglioma Pathological Image Generation
title_sort novel method based on gan using a segmentation module for oligodendroglioma pathological image generation
topic generative adversarial networks
pathology image synthesis
digital pathology
url https://www.mdpi.com/1424-8220/22/10/3960
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