PPP2R1B abolishes colorectal cancer liver metastasis and sensitizes Oxaliplatin by inhibiting MAPK/ERK signaling pathway

Abstract Background Patients with colorectal cancer (CRC) with liver metastasis or drug resistance have a poor prognosis. Previous research has demonstrated that PPP2R1B inactivation results in the development of CRC. However, the role of PPP2R1B in CRC metastasis and drug resistance is unclear. Met...

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Bibliographic Details
Main Authors: Wei Liu, Jingtong Tang, Wei Gao, Jian Sun, Gang Liu, Jianping Zhou
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cancer Cell International
Subjects:
Online Access:https://doi.org/10.1186/s12935-024-03273-w