Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A review
Antimicrobial drug resistance has become a global challenge and one of utmost concern due to the global epidemiological infections. Medicinal plants have long performed an essential role in medicine and can be an essential source of recent antimicrobials and techniques for treating resistance. Claus...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-07-01
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| Series: | Open Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/chem-2022-0176 |
| _version_ | 1828203743254937600 |
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| author | Musa Abdullahi Aminah Nanik Siti Davies-Bolorunduro Olabisi Flora Kristanti Alfinda Novi Suhaili Islami Amalina Izzatul Wai Theint Su Naing Thae Thae Su Pyae |
| author_facet | Musa Abdullahi Aminah Nanik Siti Davies-Bolorunduro Olabisi Flora Kristanti Alfinda Novi Suhaili Islami Amalina Izzatul Wai Theint Su Naing Thae Thae Su Pyae |
| author_sort | Musa Abdullahi |
| collection | DOAJ |
| description | Antimicrobial drug resistance has become a global challenge and one of utmost concern due to the global epidemiological infections. Medicinal plants have long performed an essential role in medicine and can be an essential source of recent antimicrobials and techniques for treating resistance. Clausena is a genus in the Rutaceae family which are widely recognized and utilized in traditional medicines. Many members of this genus have been a primary source of medications and drug history. The antimicrobial effectiveness of the secondary metabolites from the roots, stems, leaves, rhizomes, twigs, seeds, fruits, and flowers of several Clausena species has been widely examined and was found to be more effective against bacteria with Clausena anisata being the most promising specie. A total of 16 active compounds including 12 alkaloids, 2 coumarins, and 2 terpenoids were reported to be isolated from different parts of the plant species with mukonal being the only compound that shows dual potency both against fungi and protozoa. This review aims to sum up research advances made from 2000 to date, on the antibacterial, antifungal, and antiprotozoal activities of Clausena species, and highlight the potential use of Clausena plants in the prevention and treatment of infectious diseases. |
| first_indexed | 2024-04-12T12:10:34Z |
| format | Article |
| id | doaj.art-b8adcb9d88614d93ae66a53a598fe053 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-12T12:10:34Z |
| publishDate | 2022-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-b8adcb9d88614d93ae66a53a598fe0532022-12-22T03:33:36ZengDe GruyterOpen Chemistry2391-54202022-07-0120162765010.1515/chem-2022-0176Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A reviewMusa Abdullahi0Aminah Nanik Siti1Davies-Bolorunduro Olabisi Flora2Kristanti Alfinda Novi3Suhaili4Islami Amalina Izzatul5Wai Theint Su6Naing Thae Thae Su Pyae7Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaCentre for Tuberculosis Research, Nigerian Institute of Medical Research, Yaba, Lagos, NigeriaDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaAntimicrobial drug resistance has become a global challenge and one of utmost concern due to the global epidemiological infections. Medicinal plants have long performed an essential role in medicine and can be an essential source of recent antimicrobials and techniques for treating resistance. Clausena is a genus in the Rutaceae family which are widely recognized and utilized in traditional medicines. Many members of this genus have been a primary source of medications and drug history. The antimicrobial effectiveness of the secondary metabolites from the roots, stems, leaves, rhizomes, twigs, seeds, fruits, and flowers of several Clausena species has been widely examined and was found to be more effective against bacteria with Clausena anisata being the most promising specie. A total of 16 active compounds including 12 alkaloids, 2 coumarins, and 2 terpenoids were reported to be isolated from different parts of the plant species with mukonal being the only compound that shows dual potency both against fungi and protozoa. This review aims to sum up research advances made from 2000 to date, on the antibacterial, antifungal, and antiprotozoal activities of Clausena species, and highlight the potential use of Clausena plants in the prevention and treatment of infectious diseases.https://doi.org/10.1515/chem-2022-0176clausenaantimicrobialantibacterialantifungalinfectious diseases |
| spellingShingle | Musa Abdullahi Aminah Nanik Siti Davies-Bolorunduro Olabisi Flora Kristanti Alfinda Novi Suhaili Islami Amalina Izzatul Wai Theint Su Naing Thae Thae Su Pyae Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A review Open Chemistry clausena antimicrobial antibacterial antifungal infectious diseases |
| title | Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A review |
| title_full | Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A review |
| title_fullStr | Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A review |
| title_full_unstemmed | Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A review |
| title_short | Antimicrobial activities of the extracts and secondary metabolites from Clausena genus – A review |
| title_sort | antimicrobial activities of the extracts and secondary metabolites from clausena genus a review |
| topic | clausena antimicrobial antibacterial antifungal infectious diseases |
| url | https://doi.org/10.1515/chem-2022-0176 |
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