Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients
Background: Although smell and taste disorders are highly prevalent symptoms of COVID-19 infection, the predictive factors leading to long-lasting chemosensory dysfunction are still poorly understood. Methods: 102 out of 421 (24.2%) mildly symptomatic COVID-19 patients completed a second questionnai...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/12/8/1256 |
| _version_ | 1797432049330552832 |
|---|---|
| author | María A. Callejón-Leblic Daniel I. Martín-Jiménez Ramón Moreno-Luna Jose M. Palacios-Garcia Marta Alvarez-Cendrero Julissa A. Vizcarra-Melgar Carlos Fernandez-Velez Isabel M. Reyes-Tejero Juan Maza-Solano Jaime Gonzalez-Garcia Beatriz Tena-García María E. Acosta-Mosquera Alfonso Del Cuvillo Serafín Sánchez-Gómez |
| author_facet | María A. Callejón-Leblic Daniel I. Martín-Jiménez Ramón Moreno-Luna Jose M. Palacios-Garcia Marta Alvarez-Cendrero Julissa A. Vizcarra-Melgar Carlos Fernandez-Velez Isabel M. Reyes-Tejero Juan Maza-Solano Jaime Gonzalez-Garcia Beatriz Tena-García María E. Acosta-Mosquera Alfonso Del Cuvillo Serafín Sánchez-Gómez |
| author_sort | María A. Callejón-Leblic |
| collection | DOAJ |
| description | Background: Although smell and taste disorders are highly prevalent symptoms of COVID-19 infection, the predictive factors leading to long-lasting chemosensory dysfunction are still poorly understood. Methods: 102 out of 421 (24.2%) mildly symptomatic COVID-19 patients completed a second questionnaire about the evolution of their symptoms one year after the infection using visual analog scales (VAS). A subgroup of 69 patients also underwent psychophysical evaluation of olfactory function through UPSIT. Results: The prevalence of chemosensory dysfunction decreased from 82.4% to 45.1% after 12 months, with 46.1% of patients reporting a complete recovery. Patients older than 40 years (OR = 0.20; 95% CI: [0.07, 0.56]) and with a duration of loss of smell longer than four weeks saw a lower odds ratio for recovery (OR = 0.27; 95% CI: [0.10, 0.76]). In addition, 28 patients (35.9%) reported suffering from parosmia, which was associated with moderate to severe taste dysfunction at the baseline (OR = 7.80; 95% CI: [1.70, 35.8]). Among the 69 subjects who underwent the UPSIT, 57 (82.6%) presented some degree of smell dysfunction, showing a moderate correlation with self-reported VAS (<i>r</i> = −0.36, <i>p</i> = 0.0027). Conclusion: A clinically relevant number of subjects reported persistent chemosensory dysfunction and parosmia one year after COVID-19 infection, with a moderate correlation with psychophysical olfactory tests. |
| first_indexed | 2024-03-09T09:54:39Z |
| format | Article |
| id | doaj.art-b8af26241a4a4d36a45b75ac549c74ad |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T09:54:39Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-b8af26241a4a4d36a45b75ac549c74ad2023-12-01T23:54:46ZengMDPI AGLife2075-17292022-08-01128125610.3390/life12081256Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 PatientsMaría A. Callejón-Leblic0Daniel I. Martín-Jiménez1Ramón Moreno-Luna2Jose M. Palacios-Garcia3Marta Alvarez-Cendrero4Julissa A. Vizcarra-Melgar5Carlos Fernandez-Velez6Isabel M. Reyes-Tejero7Juan Maza-Solano8Jaime Gonzalez-Garcia9Beatriz Tena-García10María E. Acosta-Mosquera11Alfonso Del Cuvillo12Serafín Sánchez-Gómez13Rhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Virgen de Valme University Hospital, 41014 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainRhinology and Asthma Unit, ENT Department, The University Hospital of Jerez, 11407 Jerez de la Frontera, SpainRhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, 41009 Seville, SpainBackground: Although smell and taste disorders are highly prevalent symptoms of COVID-19 infection, the predictive factors leading to long-lasting chemosensory dysfunction are still poorly understood. Methods: 102 out of 421 (24.2%) mildly symptomatic COVID-19 patients completed a second questionnaire about the evolution of their symptoms one year after the infection using visual analog scales (VAS). A subgroup of 69 patients also underwent psychophysical evaluation of olfactory function through UPSIT. Results: The prevalence of chemosensory dysfunction decreased from 82.4% to 45.1% after 12 months, with 46.1% of patients reporting a complete recovery. Patients older than 40 years (OR = 0.20; 95% CI: [0.07, 0.56]) and with a duration of loss of smell longer than four weeks saw a lower odds ratio for recovery (OR = 0.27; 95% CI: [0.10, 0.76]). In addition, 28 patients (35.9%) reported suffering from parosmia, which was associated with moderate to severe taste dysfunction at the baseline (OR = 7.80; 95% CI: [1.70, 35.8]). Among the 69 subjects who underwent the UPSIT, 57 (82.6%) presented some degree of smell dysfunction, showing a moderate correlation with self-reported VAS (<i>r</i> = −0.36, <i>p</i> = 0.0027). Conclusion: A clinically relevant number of subjects reported persistent chemosensory dysfunction and parosmia one year after COVID-19 infection, with a moderate correlation with psychophysical olfactory tests.https://www.mdpi.com/2075-1729/12/8/1256olfactory disordersCOVID-19prediction modelanosmiaparosmiasmell disorders |
| spellingShingle | María A. Callejón-Leblic Daniel I. Martín-Jiménez Ramón Moreno-Luna Jose M. Palacios-Garcia Marta Alvarez-Cendrero Julissa A. Vizcarra-Melgar Carlos Fernandez-Velez Isabel M. Reyes-Tejero Juan Maza-Solano Jaime Gonzalez-Garcia Beatriz Tena-García María E. Acosta-Mosquera Alfonso Del Cuvillo Serafín Sánchez-Gómez Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients Life olfactory disorders COVID-19 prediction model anosmia parosmia smell disorders |
| title | Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients |
| title_full | Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients |
| title_fullStr | Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients |
| title_full_unstemmed | Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients |
| title_short | Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients |
| title_sort | analysis of prevalence and predictive factors of long lasting olfactory and gustatory dysfunction in covid 19 patients |
| topic | olfactory disorders COVID-19 prediction model anosmia parosmia smell disorders |
| url | https://www.mdpi.com/2075-1729/12/8/1256 |
| work_keys_str_mv | AT mariaacallejonleblic analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT danielimartinjimenez analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT ramonmorenoluna analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT josempalaciosgarcia analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT martaalvarezcendrero analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT julissaavizcarramelgar analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT carlosfernandezvelez analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT isabelmreyestejero analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT juanmazasolano analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT jaimegonzalezgarcia analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT beatriztenagarcia analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT mariaeacostamosquera analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT alfonsodelcuvillo analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients AT serafinsanchezgomez analysisofprevalenceandpredictivefactorsoflonglastingolfactoryandgustatorydysfunctionincovid19patients |