Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature Review
BackgroundRenal cell carcinoma can metastasize to virtually any anatomical site throughout the body, especially the lung, bone, lymph nodes, liver, and brain. However, it is extremely rare for renal cell carcinoma to metastasize solely to the mediastinal lymph node more than 15 years after radical n...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.593142/full |
| _version_ | 1818847772719185920 |
|---|---|
| author | Hang Lin Heng Zhang Yuanda Cheng Yuanda Cheng Yuanda Cheng Yuanda Cheng Chunfang Zhang Chunfang Zhang Chunfang Zhang Chunfang Zhang |
| author_facet | Hang Lin Heng Zhang Yuanda Cheng Yuanda Cheng Yuanda Cheng Yuanda Cheng Chunfang Zhang Chunfang Zhang Chunfang Zhang Chunfang Zhang |
| author_sort | Hang Lin |
| collection | DOAJ |
| description | BackgroundRenal cell carcinoma can metastasize to virtually any anatomical site throughout the body, especially the lung, bone, lymph nodes, liver, and brain. However, it is extremely rare for renal cell carcinoma to metastasize solely to the mediastinal lymph node more than 15 years after radical nephrectomy.Case PresentationThe case we present here is that of a 50-year-old Chinese male with an isolated posterior mediastinal lymph node metastasis of clear cell renal cell carcinoma 16 years after radical nephrectomy. However, based on imaging examination, the mass was clinically misdiagnosed as Castleman’s disease before operation. Following surgical excision of the mass, it was finally judged to be a metastasis from clear cell renal cell carcinoma according to the patient’s medical history and immunohistochemical findings. Currently, there is no clinical or radiological finding the recurrence of metastasis after 10 months of follow-up.ConclusionWe report a case of solitary metastasis in the posterior mediastinal lymph node 16 years after radical nephrectomy for clear cell renal cell carcinoma. Given the long disease-free interval between primary renal cell carcinoma to isolated mediastinal lymph node metastasis, it is important to conduct a lifelong regular follow-up, including thoracic computed tomography. In addition, surgical resection remains the best method of treatment for mediastinal lymph node metastases from clear cell renal cell carcinoma if the metastatic lesion is limited. |
| first_indexed | 2024-12-19T06:06:46Z |
| format | Article |
| id | doaj.art-b8afe8059857415a9a20b1e70a67e16b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T06:06:46Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b8afe8059857415a9a20b1e70a67e16b2022-12-21T20:33:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.593142593142Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature ReviewHang Lin0Heng Zhang1Yuanda Cheng2Yuanda Cheng3Yuanda Cheng4Yuanda Cheng5Chunfang Zhang6Chunfang Zhang7Chunfang Zhang8Chunfang Zhang9Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaHuman Engineering Research Center for Pulmonary Nodules Precise Diagnosis and Treatment, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaXiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaHuman Engineering Research Center for Pulmonary Nodules Precise Diagnosis and Treatment, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaXiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, ChinaBackgroundRenal cell carcinoma can metastasize to virtually any anatomical site throughout the body, especially the lung, bone, lymph nodes, liver, and brain. However, it is extremely rare for renal cell carcinoma to metastasize solely to the mediastinal lymph node more than 15 years after radical nephrectomy.Case PresentationThe case we present here is that of a 50-year-old Chinese male with an isolated posterior mediastinal lymph node metastasis of clear cell renal cell carcinoma 16 years after radical nephrectomy. However, based on imaging examination, the mass was clinically misdiagnosed as Castleman’s disease before operation. Following surgical excision of the mass, it was finally judged to be a metastasis from clear cell renal cell carcinoma according to the patient’s medical history and immunohistochemical findings. Currently, there is no clinical or radiological finding the recurrence of metastasis after 10 months of follow-up.ConclusionWe report a case of solitary metastasis in the posterior mediastinal lymph node 16 years after radical nephrectomy for clear cell renal cell carcinoma. Given the long disease-free interval between primary renal cell carcinoma to isolated mediastinal lymph node metastasis, it is important to conduct a lifelong regular follow-up, including thoracic computed tomography. In addition, surgical resection remains the best method of treatment for mediastinal lymph node metastases from clear cell renal cell carcinoma if the metastatic lesion is limited.https://www.frontiersin.org/articles/10.3389/fonc.2020.593142/fullrenal cell carcinomaclear cell renal cell carcinomasolitary metastasisposterior mediastinal lymph nodesurgical resection |
| spellingShingle | Hang Lin Heng Zhang Yuanda Cheng Yuanda Cheng Yuanda Cheng Yuanda Cheng Chunfang Zhang Chunfang Zhang Chunfang Zhang Chunfang Zhang Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature Review Frontiers in Oncology renal cell carcinoma clear cell renal cell carcinoma solitary metastasis posterior mediastinal lymph node surgical resection |
| title | Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature Review |
| title_full | Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature Review |
| title_fullStr | Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature Review |
| title_full_unstemmed | Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature Review |
| title_short | Solitary Metastasis in the Mediastinal Lymph Node After Radical Nephrectomy for Clear Cell Renal Cell Carcinoma: A Case Report and Literature Review |
| title_sort | solitary metastasis in the mediastinal lymph node after radical nephrectomy for clear cell renal cell carcinoma a case report and literature review |
| topic | renal cell carcinoma clear cell renal cell carcinoma solitary metastasis posterior mediastinal lymph node surgical resection |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.593142/full |
| work_keys_str_mv | AT hanglin solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT hengzhang solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT yuandacheng solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT yuandacheng solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT yuandacheng solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT yuandacheng solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT chunfangzhang solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT chunfangzhang solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT chunfangzhang solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview AT chunfangzhang solitarymetastasisinthemediastinallymphnodeafterradicalnephrectomyforclearcellrenalcellcarcinomaacasereportandliteraturereview |