LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis
AbstractLong non-coding RNAs and microRNAs are functional regulators in tumour progression. Herein, we revealed the level LINC02163 was up-regulated in CRC tissues and cell lines, and the expression of LINC02163 negatively correlated with prognosis of CRC patients. Functional experiments demonstrate...
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| Format: | Article |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2020.1773486 |
| _version_ | 1797788829378150400 |
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| author | Junwen Ma Lihai Zhang Anquan Shang Hu Song Jiege Huo Mingjian Zhang Liuqin Jiang |
| author_facet | Junwen Ma Lihai Zhang Anquan Shang Hu Song Jiege Huo Mingjian Zhang Liuqin Jiang |
| author_sort | Junwen Ma |
| collection | DOAJ |
| description | AbstractLong non-coding RNAs and microRNAs are functional regulators in tumour progression. Herein, we revealed the level LINC02163 was up-regulated in CRC tissues and cell lines, and the expression of LINC02163 negatively correlated with prognosis of CRC patients. Functional experiments demonstrated knockdown of LINC02163 significantly attenuated CRC cells proliferation and metastasis. Mechanism analysis showed miR-511-3p could bind LINC02163 and AKT3, and the expressional level of miR-511-3p negatively correlated with the abundance of LINC02163 and AKT3. Inhibition of LINC02163 suppressed cell proliferation, while transfection of miR-511-3p inhibitor or AKT3 in LINC02163-depletion cells restored cell growth and abolished the cell cycle arrest in G0/G1 phase. Therefore, it was indicated that LINC02163 exerted pro-tumour effect through miR-511-3p/AKT3 axis and was prognostic marker for colorectal cancer. |
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| format | Article |
| id | doaj.art-b8b0d6423873438d83697dc572a462cb |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-13T01:41:02Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
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| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-b8b0d6423873438d83697dc572a462cb2023-07-03T14:04:56ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-0148196196810.1080/21691401.2020.1773486LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axisJunwen Ma0Lihai Zhang1Anquan Shang2Hu Song3Jiege Huo4Mingjian Zhang5Liuqin Jiang6Department of Gastrointestinal Surgery, The General Hospital of Ningxia Medical University, Yinchuan, ChinaDepartment of General Surgery and Pediatrics, The First Affiliated Hospital of Jiamusi University, Jiamusi, ChinaDepartment of Laboratory Medicine, The Sixth People’s Hospital of Yancheng City, Yancheng, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Oncology, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaCenter of Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaAbstractLong non-coding RNAs and microRNAs are functional regulators in tumour progression. Herein, we revealed the level LINC02163 was up-regulated in CRC tissues and cell lines, and the expression of LINC02163 negatively correlated with prognosis of CRC patients. Functional experiments demonstrated knockdown of LINC02163 significantly attenuated CRC cells proliferation and metastasis. Mechanism analysis showed miR-511-3p could bind LINC02163 and AKT3, and the expressional level of miR-511-3p negatively correlated with the abundance of LINC02163 and AKT3. Inhibition of LINC02163 suppressed cell proliferation, while transfection of miR-511-3p inhibitor or AKT3 in LINC02163-depletion cells restored cell growth and abolished the cell cycle arrest in G0/G1 phase. Therefore, it was indicated that LINC02163 exerted pro-tumour effect through miR-511-3p/AKT3 axis and was prognostic marker for colorectal cancer.https://www.tandfonline.com/doi/10.1080/21691401.2020.1773486Colorectal cancerLINC02163MiR-511-3pAKT3cell cycle arrest |
| spellingShingle | Junwen Ma Lihai Zhang Anquan Shang Hu Song Jiege Huo Mingjian Zhang Liuqin Jiang LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis Artificial Cells, Nanomedicine, and Biotechnology Colorectal cancer LINC02163 MiR-511-3p AKT3 cell cycle arrest |
| title | LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis |
| title_full | LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis |
| title_fullStr | LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis |
| title_full_unstemmed | LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis |
| title_short | LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis |
| title_sort | linc02163 promotes colorectal cancer progression via mir 511 3p akt3 axis |
| topic | Colorectal cancer LINC02163 MiR-511-3p AKT3 cell cycle arrest |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2020.1773486 |
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