Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria
Malaria is caused by infection with Plasmodium parasites. Various studies with knockout mice have indicated that IFN-γ plays essential roles in protective immunity against blood-stage Plasmodium infection. However, after Plasmodium infection, increased IFN-γ production by various types of cells is i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00258/full |
| _version_ | 1811204078057816064 |
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| author | Shin-Ichi eInoue Mamoru eNiikura Shoichiro eMineo Fumie eKobayashi |
| author_facet | Shin-Ichi eInoue Mamoru eNiikura Shoichiro eMineo Fumie eKobayashi |
| author_sort | Shin-Ichi eInoue |
| collection | DOAJ |
| description | Malaria is caused by infection with Plasmodium parasites. Various studies with knockout mice have indicated that IFN-γ plays essential roles in protective immunity against blood-stage Plasmodium infection. However, after Plasmodium infection, increased IFN-γ production by various types of cells is involved not only in protective immunity, but also in immunopathology. Recent reports have shown that IFN-γ acts as a pro-inflammatory cytokine to induce not only the activation of macrophages, but also the generation of uncommon myelolymphoid progenitor cells after Plasmodium infection. However, the effects of IFN-γ on hematopoietic stem cells and progenitor cells are unclear. Therefore, the regulation of hematopoiesis by IFN-γ during Plasmodium infection remains to be clarified. Although there are conflicting reports concerning the significance of γδ T cells in protective immunity against Plasmodium infection, γδ T cells may respond to infection and produce IFN-γ as innate immune cells in the early phase of blood-stage malaria. Our recent studies have shown that γδ T cells express CD40 ligand and produce IFN-γ after Plasmodium infection, resulting in the enhancement of dendritic cell activation as part of the immune response to eliminate Plasmodium parasites. These data suggest that the function of γδ T cells is similar to that of NK cells. Although several reports suggest that γδ T cells have the potential to act as memory cells for various infections, it remains to be determined whether memory γδ T cells are generated by Plasmodium infection and whether memory γδ T cells can contribute to the host defense against re-infection with Plasmodium. Here, we summarize and discuss the effects of IFN-γ and the various functions of γδ T cells in blood-stage Plasmodium infection. |
| first_indexed | 2024-04-12T03:05:16Z |
| format | Article |
| id | doaj.art-b8b0d66caba14cba85c09f857efb4930 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T03:05:16Z |
| publishDate | 2013-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b8b0d66caba14cba85c09f857efb49302022-12-22T03:50:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-08-01410.3389/fimmu.2013.0025850739Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malariaShin-Ichi eInoue0Mamoru eNiikura1Shoichiro eMineo2Fumie eKobayashi3Kyorin University School of MedicineKyorin University School of MedicineKyorin University School of MedicineKyorin University School of MedicineMalaria is caused by infection with Plasmodium parasites. Various studies with knockout mice have indicated that IFN-γ plays essential roles in protective immunity against blood-stage Plasmodium infection. However, after Plasmodium infection, increased IFN-γ production by various types of cells is involved not only in protective immunity, but also in immunopathology. Recent reports have shown that IFN-γ acts as a pro-inflammatory cytokine to induce not only the activation of macrophages, but also the generation of uncommon myelolymphoid progenitor cells after Plasmodium infection. However, the effects of IFN-γ on hematopoietic stem cells and progenitor cells are unclear. Therefore, the regulation of hematopoiesis by IFN-γ during Plasmodium infection remains to be clarified. Although there are conflicting reports concerning the significance of γδ T cells in protective immunity against Plasmodium infection, γδ T cells may respond to infection and produce IFN-γ as innate immune cells in the early phase of blood-stage malaria. Our recent studies have shown that γδ T cells express CD40 ligand and produce IFN-γ after Plasmodium infection, resulting in the enhancement of dendritic cell activation as part of the immune response to eliminate Plasmodium parasites. These data suggest that the function of γδ T cells is similar to that of NK cells. Although several reports suggest that γδ T cells have the potential to act as memory cells for various infections, it remains to be determined whether memory γδ T cells are generated by Plasmodium infection and whether memory γδ T cells can contribute to the host defense against re-infection with Plasmodium. Here, we summarize and discuss the effects of IFN-γ and the various functions of γδ T cells in blood-stage Plasmodium infection.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00258/fullDendritic CellsHematopoiesisMalariamemory cellsγδ T cellsIFN-γ |
| spellingShingle | Shin-Ichi eInoue Mamoru eNiikura Shoichiro eMineo Fumie eKobayashi Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria Frontiers in Immunology Dendritic Cells Hematopoiesis Malaria memory cells γδ T cells IFN-γ |
| title | Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria |
| title_full | Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria |
| title_fullStr | Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria |
| title_full_unstemmed | Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria |
| title_short | Roles of IFN-γ and γδ T cells in protective immunity against blood-stage malaria |
| title_sort | roles of ifn γ and γδ t cells in protective immunity against blood stage malaria |
| topic | Dendritic Cells Hematopoiesis Malaria memory cells γδ T cells IFN-γ |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00258/full |
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