Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine
By this article, we have reflected results of a valuable study in which by chemometric modeling of different types of electrochemical data, binding and inhibition of the calcineurin (CN) by cyclosporine (CsA) has been thoroughly investigated. Firstly, analysis of the electrochemical data by conventi...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180420301185 |
| _version_ | 1818160983032463360 |
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| author | Ali R. Jalalvand |
| author_facet | Ali R. Jalalvand |
| author_sort | Ali R. Jalalvand |
| collection | DOAJ |
| description | By this article, we have reflected results of a valuable study in which by chemometric modeling of different types of electrochemical data, binding and inhibition of the calcineurin (CN) by cyclosporine (CsA) has been thoroughly investigated. Firstly, analysis of the electrochemical data by conventional methods was performed which helped us to extract some information to cast an initial look at interactions of CsA with CN. Then, electrochemical data were modeled by hard-modeling chemometric methods to obtain some quantitative information about binding of CsA with CN and subsequently, the electrochemical data were row-wise augmented and analyzed by multivariate curve resolution-alternating least squares as a well-known soft modeling chemometric tool to extract qualitative information about mentioned interactions. Both of hard- and soft-modeling methods gave us the results which were compatible and confirmed the results of the first step which were obtained by conventional methods. Finally, an amperometric method was developed for determination of the CN according to its binding and inhibition by CsA. |
| first_indexed | 2024-12-11T16:10:32Z |
| format | Article |
| id | doaj.art-b8b1e996a8e44d33beaa2bee6f2c0251 |
| institution | Directory Open Access Journal |
| issn | 2214-1804 |
| language | English |
| last_indexed | 2024-12-11T16:10:32Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj.art-b8b1e996a8e44d33beaa2bee6f2c02512022-12-22T00:59:05ZengElsevierSensing and Bio-Sensing Research2214-18042020-08-0129100361Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporineAli R. Jalalvand0Corresponding Author.; Research Center of Oils and Fats, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, IranBy this article, we have reflected results of a valuable study in which by chemometric modeling of different types of electrochemical data, binding and inhibition of the calcineurin (CN) by cyclosporine (CsA) has been thoroughly investigated. Firstly, analysis of the electrochemical data by conventional methods was performed which helped us to extract some information to cast an initial look at interactions of CsA with CN. Then, electrochemical data were modeled by hard-modeling chemometric methods to obtain some quantitative information about binding of CsA with CN and subsequently, the electrochemical data were row-wise augmented and analyzed by multivariate curve resolution-alternating least squares as a well-known soft modeling chemometric tool to extract qualitative information about mentioned interactions. Both of hard- and soft-modeling methods gave us the results which were compatible and confirmed the results of the first step which were obtained by conventional methods. Finally, an amperometric method was developed for determination of the CN according to its binding and inhibition by CsA.http://www.sciencedirect.com/science/article/pii/S2214180420301185CalcineurinCyclosporineInhibition |
| spellingShingle | Ali R. Jalalvand Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine Sensing and Bio-Sensing Research Calcineurin Cyclosporine Inhibition |
| title | Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine |
| title_full | Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine |
| title_fullStr | Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine |
| title_full_unstemmed | Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine |
| title_short | Chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine |
| title_sort | chemometric modeling of different types of electrochemical data for investigation of the binding and inhibition of calcineurin by cyclosporine |
| topic | Calcineurin Cyclosporine Inhibition |
| url | http://www.sciencedirect.com/science/article/pii/S2214180420301185 |
| work_keys_str_mv | AT alirjalalvand chemometricmodelingofdifferenttypesofelectrochemicaldataforinvestigationofthebindingandinhibitionofcalcineurinbycyclosporine |