Cholesterol and Sphingomyelin Polarize at the Leading Edge of Migrating Myoblasts and Involve Their Clustering in Submicrometric Domains

Cholesterol and Sphingomyelin Polarize at the Leading Edge of Migrating Myoblasts and Involve Their Clustering in Submicrometric Domains

Myoblast migration is crucial for myogenesis and muscular tissue homeostasis. However, its spatiotemporal control remains elusive. Here, we explored the involvement of plasma membrane cholesterol and sphingolipids in this process. In resting C2C12 mouse myoblasts, those lipids clustered in sphingomy...

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Bibliographic Details
Main Authors: Juliette Vanderroost, Noémie Avalosse, Danahe Mohammed, Delia Hoffmann, Patrick Henriet, Christophe E. Pierreux, David Alsteens, Donatienne Tyteca
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
membrane lateral heterogeneity
Airyscan microscopy
atomic force microscopy
GM1 ganglioside
focal adhesion
actin cytoskeleton
Online Access:https://www.mdpi.com/2218-273X/13/2/319

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