Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation
Diabetes treatment requires focused administration with quality systemic circulation to determine the optimal therapeutic window. Intestinal distribution through oral administration with nanoformulation provides several benefits. Therefore, the purpose of this study is to create plumbagin enclosed w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/8/1169 |
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| author | Rama Tyagi Ayesha Waheed Neeraj Kumar Abdul Ahad Yousef A. Bin Jardan Mohd. Mujeeb Ashok Kumar Tanveer Naved Swati Madan |
| author_facet | Rama Tyagi Ayesha Waheed Neeraj Kumar Abdul Ahad Yousef A. Bin Jardan Mohd. Mujeeb Ashok Kumar Tanveer Naved Swati Madan |
| author_sort | Rama Tyagi |
| collection | DOAJ |
| description | Diabetes treatment requires focused administration with quality systemic circulation to determine the optimal therapeutic window. Intestinal distribution through oral administration with nanoformulation provides several benefits. Therefore, the purpose of this study is to create plumbagin enclosed within niosomes using the quality by design (QbD) strategy for efficient penetration and increased bioavailability. The formulation and optimization of plumbagin-loaded niosomes (P-Ns-Opt) involved the use of a Box–Behnken Design. The particle size (PDI) and entrapment efficiency of the optimized P-Ns-Opt were 133.6 nm, 0.150, and 75.6%, respectively. TEM, DSC, and FTIR were used to analyze the morphology and compatibility of the optimized P-Ns-Opt. Studies conducted in vitro revealed a controlled release system. P-Ns-Opt’s antioxidant activity, α-amylase, and α-glucosidase were evaluated, and the results revealed a dose-dependent efficacy with 60.68 ± 0.02%,90.69 ± 2.9%, and 88.43 ± 0.89%, respectively. In summary, the created P-Ns-Opt demonstrate remarkable potential for antidiabetic activity by inhibiting oxygen radicals, α-amylase, and α-glucosidase enzymes and are, therefore, a promising drug delivery nanocarrier in the management and treatment of diabetes. |
| first_indexed | 2024-03-10T23:39:51Z |
| format | Article |
| id | doaj.art-b8b670012c234d29863b662b354f43ff |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T23:39:51Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-b8b670012c234d29863b662b354f43ff2023-11-19T02:35:04ZengMDPI AGPharmaceuticals1424-82472023-08-01168116910.3390/ph16081169Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro EvaluationRama Tyagi0Ayesha Waheed1Neeraj Kumar2Abdul Ahad3Yousef A. Bin Jardan4Mohd. Mujeeb5Ashok Kumar6Tanveer Naved7Swati Madan8Amity Institute of Pharmacy, Amity University, Noida 201303, Uttar Pradesh, IndiaDepartment of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, M. B. Road, New Delhi 110062, IndiaDepartment of Pharmacognosy & Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, M. B. Road, New Delhi 110062, IndiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy & Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, M. B. Road, New Delhi 110062, IndiaDepartment of Internal Medicine, University of Kansas Medical Centre, Kansas City, KS 66160, USAAmity Institute of Pharmacy, Amity University, Noida 201303, Uttar Pradesh, IndiaAmity Institute of Pharmacy, Amity University, Noida 201303, Uttar Pradesh, IndiaDiabetes treatment requires focused administration with quality systemic circulation to determine the optimal therapeutic window. Intestinal distribution through oral administration with nanoformulation provides several benefits. Therefore, the purpose of this study is to create plumbagin enclosed within niosomes using the quality by design (QbD) strategy for efficient penetration and increased bioavailability. The formulation and optimization of plumbagin-loaded niosomes (P-Ns-Opt) involved the use of a Box–Behnken Design. The particle size (PDI) and entrapment efficiency of the optimized P-Ns-Opt were 133.6 nm, 0.150, and 75.6%, respectively. TEM, DSC, and FTIR were used to analyze the morphology and compatibility of the optimized P-Ns-Opt. Studies conducted in vitro revealed a controlled release system. P-Ns-Opt’s antioxidant activity, α-amylase, and α-glucosidase were evaluated, and the results revealed a dose-dependent efficacy with 60.68 ± 0.02%,90.69 ± 2.9%, and 88.43 ± 0.89%, respectively. In summary, the created P-Ns-Opt demonstrate remarkable potential for antidiabetic activity by inhibiting oxygen radicals, α-amylase, and α-glucosidase enzymes and are, therefore, a promising drug delivery nanocarrier in the management and treatment of diabetes.https://www.mdpi.com/1424-8247/16/8/1169quality by designplumbagindiabetesin vitroniosomes |
| spellingShingle | Rama Tyagi Ayesha Waheed Neeraj Kumar Abdul Ahad Yousef A. Bin Jardan Mohd. Mujeeb Ashok Kumar Tanveer Naved Swati Madan Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation Pharmaceuticals quality by design plumbagin diabetes in vitro niosomes |
| title | Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation |
| title_full | Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation |
| title_fullStr | Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation |
| title_full_unstemmed | Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation |
| title_short | Formulation and Evaluation of Plumbagin-Loaded Niosomes for an Antidiabetic Study: Optimization and In Vitro Evaluation |
| title_sort | formulation and evaluation of plumbagin loaded niosomes for an antidiabetic study optimization and in vitro evaluation |
| topic | quality by design plumbagin diabetes in vitro niosomes |
| url | https://www.mdpi.com/1424-8247/16/8/1169 |
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