Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models
NPY is among the most abundant neuropeptides in vertebrate brain and is primarily involved in the regulation of food intake. The NPY system is also associated with the aging process showing beneficial effects on neuronal survival via autophagy modulation. Here, we explore the age-related regulation...
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3839 |
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| author | Daniela Giaquinto Elena De Felice Chiara Attanasio Antonio Palladino Valentina Schiano Ernesto Mollo Carla Lucini Paolo de Girolamo Livia D’Angelo |
| author_facet | Daniela Giaquinto Elena De Felice Chiara Attanasio Antonio Palladino Valentina Schiano Ernesto Mollo Carla Lucini Paolo de Girolamo Livia D’Angelo |
| author_sort | Daniela Giaquinto |
| collection | DOAJ |
| description | NPY is among the most abundant neuropeptides in vertebrate brain and is primarily involved in the regulation of food intake. The NPY system is also associated with the aging process showing beneficial effects on neuronal survival via autophagy modulation. Here, we explore the age-related regulation of NPY in the brain and foregut of the shortest- and longest-lived fish species, Nothobranchius furzeri and Danio rerio, respectively. These two research models, despite some similarities, display profound biological differences making them attractive vertebrates to elucidate the mechanisms underlying the regulation of neuropeptide synthesis and function. It is noteworthy that in both fish species only Npya has been identified, while in the other teleosts two classes of NPY (Npya and Npyb) have been annotated. Our findings document that in both species: (i) NPY is centrally regulated; (ii) NPY levels increase in the brain during aging; (iii) NPY is localized in the enteroendocrine cells as well as in the myenteric plexus and drastically decreases in old animals. According to our data, the age-related regulation in the gut resembles that described in other vertebrate species while the increased levels in the brain offer the unique possibility to explore the role of NPY in model organisms to develop future experimental and translatable approaches. |
| first_indexed | 2024-03-09T11:45:47Z |
| format | Article |
| id | doaj.art-b8b68e47c5a648468c2f8e16361f1f74 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:45:47Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b8b68e47c5a648468c2f8e16361f1f742023-11-30T23:22:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237383910.3390/ijms23073839Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational ModelsDaniela Giaquinto0Elena De Felice1Chiara Attanasio2Antonio Palladino3Valentina Schiano4Ernesto Mollo5Carla Lucini6Paolo de Girolamo7Livia D’Angelo8Department Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyConsiglio Nazionale delle Ricerche-Istituto di Chimica Biomolecolare (CNR-ICB), Via Campi Flegrei 34, 80078 Pozzuoli, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyNPY is among the most abundant neuropeptides in vertebrate brain and is primarily involved in the regulation of food intake. The NPY system is also associated with the aging process showing beneficial effects on neuronal survival via autophagy modulation. Here, we explore the age-related regulation of NPY in the brain and foregut of the shortest- and longest-lived fish species, Nothobranchius furzeri and Danio rerio, respectively. These two research models, despite some similarities, display profound biological differences making them attractive vertebrates to elucidate the mechanisms underlying the regulation of neuropeptide synthesis and function. It is noteworthy that in both fish species only Npya has been identified, while in the other teleosts two classes of NPY (Npya and Npyb) have been annotated. Our findings document that in both species: (i) NPY is centrally regulated; (ii) NPY levels increase in the brain during aging; (iii) NPY is localized in the enteroendocrine cells as well as in the myenteric plexus and drastically decreases in old animals. According to our data, the age-related regulation in the gut resembles that described in other vertebrate species while the increased levels in the brain offer the unique possibility to explore the role of NPY in model organisms to develop future experimental and translatable approaches.https://www.mdpi.com/1422-0067/23/7/3839neuropeptidesbrainagingAfrican turquoise killifishzebrafishbrain |
| spellingShingle | Daniela Giaquinto Elena De Felice Chiara Attanasio Antonio Palladino Valentina Schiano Ernesto Mollo Carla Lucini Paolo de Girolamo Livia D’Angelo Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models International Journal of Molecular Sciences neuropeptides brain aging African turquoise killifish zebrafish brain |
| title | Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models |
| title_full | Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models |
| title_fullStr | Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models |
| title_full_unstemmed | Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models |
| title_short | Central and Peripheral NPY Age-Related Regulation: A Comparative Analysis in Fish Translational Models |
| title_sort | central and peripheral npy age related regulation a comparative analysis in fish translational models |
| topic | neuropeptides brain aging African turquoise killifish zebrafish brain |
| url | https://www.mdpi.com/1422-0067/23/7/3839 |
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