Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive Insights
Chronic cerebral ischemia hypoperfusion plays a role in the initiation and progression of vascular dementia, which causes changes in metabolites. Currently, there is no standard treatment to treat, prevent and reduce the severity of this condition. Thai herbal Yahom no.20 (YHF20) is indicated for fa...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024040581 |
| _version_ | 1797247826053300224 |
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| author | Pravit Akarasereenont Saracha Pattanapholkornsakul Suveerawan Limsuvan Dollaporn Mamaethong Suksalin Booranasubkajorn Narawut Pakaprot Pinpat Tripatara Kajee Pilakasiri |
| author_facet | Pravit Akarasereenont Saracha Pattanapholkornsakul Suveerawan Limsuvan Dollaporn Mamaethong Suksalin Booranasubkajorn Narawut Pakaprot Pinpat Tripatara Kajee Pilakasiri |
| author_sort | Pravit Akarasereenont |
| collection | DOAJ |
| description | Chronic cerebral ischemia hypoperfusion plays a role in the initiation and progression of vascular dementia, which causes changes in metabolites. Currently, there is no standard treatment to treat, prevent and reduce the severity of this condition. Thai herbal Yahom no.20 (YHF20) is indicated for fatigue and dizziness. The components of YHF20 have been found to have pharmacological effects related to the pathology of chronic cerebral ischemia hypoperfusion. This study aimed to investigate metabolomic changes after YHF20 administration in a rat model of permanent bilateral common carotid artery occlusion (2-VO) induced chronic cerebral ischemia hypoperfusion, and to explore its impact on spatial learning and memory. Albino Wistar rats were randomly allocated to 5 groups; sham, 2-VO, 2-VO+ 100 mg/kg YHF20, 2-VO+300 mg/kg YHF20, and 2-VO+1000 mg/kg YHF20. The rats were administered YHF20 daily by oral gavage for 56 days after 2-VO induction. Plasma was collected weekly for metabolome change analysis using LC-MS/QTof and toxicity study. The rats were evaluated for spatial learning and memory using the Morris water maze. The results showed that 78 known metabolites and 10 tentative pathways altered after chronic cerebral hypoperfusion, although it was not able to determine the effect on memory and learning behaviors of rats. Glutathione and glutathione metabolism might be metabolite-pathway that were the affect after YHF20 administration in cerebral ischemic condition. The 4 known metabolites may be the metabolites from the constituents of YHF20 could be considered and confirmed for quality control purpose. In conclusion, YHF20 administration might contribute to metabolic changes related to cerebral ischemia condition without the effect on spatial learning and memory, including hepatotoxicity and nephrotoxicity after 56 days of treatment. Alterations in the potential metabolites may provide data support for elucidating dementia pathogenesis and selecting pathways for intervention. |
| first_indexed | 2024-04-24T20:04:51Z |
| format | Article |
| id | doaj.art-b8b8ce0aaa544720a23e6451f6d5ea79 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T20:04:51Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b8b8ce0aaa544720a23e6451f6d5ea792024-03-24T06:59:36ZengElsevierHeliyon2405-84402024-04-01107e28027Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive InsightsPravit Akarasereenont0Saracha Pattanapholkornsakul1Suveerawan Limsuvan2Dollaporn Mamaethong3Suksalin Booranasubkajorn4Narawut Pakaprot5Pinpat Tripatara6Kajee Pilakasiri7Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, Thailand; Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, Thailand; Siriraj Metabolomics and Phenomics Center, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, Thailand; Corresponding author. Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, Thailand.Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, ThailandCenter of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, ThailandCenter of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, ThailandCenter of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, ThailandDepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, ThailandDepartment of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, ThailandDepartment of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University, 10700, Bangkok, ThailandChronic cerebral ischemia hypoperfusion plays a role in the initiation and progression of vascular dementia, which causes changes in metabolites. Currently, there is no standard treatment to treat, prevent and reduce the severity of this condition. Thai herbal Yahom no.20 (YHF20) is indicated for fatigue and dizziness. The components of YHF20 have been found to have pharmacological effects related to the pathology of chronic cerebral ischemia hypoperfusion. This study aimed to investigate metabolomic changes after YHF20 administration in a rat model of permanent bilateral common carotid artery occlusion (2-VO) induced chronic cerebral ischemia hypoperfusion, and to explore its impact on spatial learning and memory. Albino Wistar rats were randomly allocated to 5 groups; sham, 2-VO, 2-VO+ 100 mg/kg YHF20, 2-VO+300 mg/kg YHF20, and 2-VO+1000 mg/kg YHF20. The rats were administered YHF20 daily by oral gavage for 56 days after 2-VO induction. Plasma was collected weekly for metabolome change analysis using LC-MS/QTof and toxicity study. The rats were evaluated for spatial learning and memory using the Morris water maze. The results showed that 78 known metabolites and 10 tentative pathways altered after chronic cerebral hypoperfusion, although it was not able to determine the effect on memory and learning behaviors of rats. Glutathione and glutathione metabolism might be metabolite-pathway that were the affect after YHF20 administration in cerebral ischemic condition. The 4 known metabolites may be the metabolites from the constituents of YHF20 could be considered and confirmed for quality control purpose. In conclusion, YHF20 administration might contribute to metabolic changes related to cerebral ischemia condition without the effect on spatial learning and memory, including hepatotoxicity and nephrotoxicity after 56 days of treatment. Alterations in the potential metabolites may provide data support for elucidating dementia pathogenesis and selecting pathways for intervention.http://www.sciencedirect.com/science/article/pii/S2405844024040581YAHOM20YHF20Cerebral ischemiaMetabolomicsCognitive impairmentThai herbal formula |
| spellingShingle | Pravit Akarasereenont Saracha Pattanapholkornsakul Suveerawan Limsuvan Dollaporn Mamaethong Suksalin Booranasubkajorn Narawut Pakaprot Pinpat Tripatara Kajee Pilakasiri Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive Insights Heliyon YAHOM20 YHF20 Cerebral ischemia Metabolomics Cognitive impairment Thai herbal formula |
| title | Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive Insights |
| title_full | Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive Insights |
| title_fullStr | Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive Insights |
| title_full_unstemmed | Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive Insights |
| title_short | Therapeutic potential of Thai herbal formula for cognitive impairment: A metabolomics approach for Comprehensive Insights |
| title_sort | therapeutic potential of thai herbal formula for cognitive impairment a metabolomics approach for comprehensive insights |
| topic | YAHOM20 YHF20 Cerebral ischemia Metabolomics Cognitive impairment Thai herbal formula |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024040581 |
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