Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26
Five new oxygenated pimarane diterpenes, named scopararanes C–G (1–5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-02-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/10/3/539/ |
| _version_ | 1798041289352019968 |
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| author | Feijun Dan Weimin Zhang Yuchan Chen Meihua Tao Li Sun Dongli Li |
| author_facet | Feijun Dan Weimin Zhang Yuchan Chen Meihua Tao Li Sun Dongli Li |
| author_sort | Feijun Dan |
| collection | DOAJ |
| description | Five new oxygenated pimarane diterpenes, named scopararanes C–G (1–5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1–5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1–5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method. |
| first_indexed | 2024-04-11T22:19:26Z |
| format | Article |
| id | doaj.art-b8b91f396d354cde8b749b23289b52bf |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:19:26Z |
| publishDate | 2012-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b8b91f396d354cde8b749b23289b52bf2022-12-22T04:00:14ZengMDPI AGMarine Drugs1660-33972012-02-0110353955010.3390/md10030539Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26Feijun DanWeimin ZhangYuchan ChenMeihua TaoLi SunDongli LiFive new oxygenated pimarane diterpenes, named scopararanes C–G (1–5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1–5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1–5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.http://www.mdpi.com/1660-3397/10/3/539/pimarane diterpenesmarine sediment-derived fungusEutypella scopariaSouth China Seacytotoxic activity |
| spellingShingle | Feijun Dan Weimin Zhang Yuchan Chen Meihua Tao Li Sun Dongli Li Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26 Marine Drugs pimarane diterpenes marine sediment-derived fungus Eutypella scoparia South China Sea cytotoxic activity |
| title | Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26 |
| title_full | Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26 |
| title_fullStr | Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26 |
| title_full_unstemmed | Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26 |
| title_short | Scopararanes C–G: New Oxygenated Pimarane Diterpenes from the Marine Sediment-Derived Fungus Eutypella scoparia FS26 |
| title_sort | scopararanes c g new oxygenated pimarane diterpenes from the marine sediment derived fungus eutypella scoparia fs26 |
| topic | pimarane diterpenes marine sediment-derived fungus Eutypella scoparia South China Sea cytotoxic activity |
| url | http://www.mdpi.com/1660-3397/10/3/539/ |
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