Increase of solubility and transmembrane permeability of niclosamide from its mechanochemically synthesized solid dispersions

Increase of solubility and transmembrane permeability of niclosamide from its mechanochemically synthesized solid dispersions

More than 4.5 billion people worldwide are affected by parasitic diseases, with helminth infections accounting for 99% of the total number. Niclosamide (NS) is a weakly acidic active pharmaceutical ingredient (API) used to treat helminth infections. However, the pharmaceutical use of pure niclosamid...

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Bibliographic Details
Main Authors: Elizaveta S. Meteleva, Elizaveta A. Roenko, Nikolay E. Polyakov
Format: Article
Language:English
Published: Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2023-08-01
Series:Chimica Techno Acta
Subjects:
niclosamide
solubility enhancement
solid dispersions
mechanochemical synthesis
hydroxypropyl-β-cyclodextrin
calcium carbonate
n-methyl-d-glucamine
Online Access:https://journals.urfu.ru/index.php/chimtech/article/view/6904

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https://journals.urfu.ru/index.php/chimtech/article/view/6904

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