Visceral Obesity in Non-Small Cell Lung Cancer
While obesity measured by body mass index (BMI) has been paradoxically associated with reduced risk and better outcome for lung cancer, recent studies suggest that the harm of obesity becomes apparent when measured as visceral adiposity. However, the prevalence of visceral obesity and its associatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/14/3450 |
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| author | Lindsay Nitsche Yeshwanth Vedire Eric Kannisto Xiaolong Wang Robert J. Seager Sarabjot Pabla Santosh K. Patnaik Sai Yendamuri |
| author_facet | Lindsay Nitsche Yeshwanth Vedire Eric Kannisto Xiaolong Wang Robert J. Seager Sarabjot Pabla Santosh K. Patnaik Sai Yendamuri |
| author_sort | Lindsay Nitsche |
| collection | DOAJ |
| description | While obesity measured by body mass index (BMI) has been paradoxically associated with reduced risk and better outcome for lung cancer, recent studies suggest that the harm of obesity becomes apparent when measured as visceral adiposity. However, the prevalence of visceral obesity and its associations with demographic and tumor features are not established. We therefore conducted an observational study of visceral obesity in 994 non-small cell lung cancer (NSCLC) patients treated during 2008–2020 at our institution. Routine computerized tomography (CT) images of the patients, obtained within a year of tumor resection or biopsy, were used to measure cross-sectional abdominal fat areas. Important aspects of the measurement approach such as inter-observer variability and time stability were examined. Visceral obesity was semi-quantified as visceral fat index (VFI), the fraction of fat area that was visceral. VFI was found to be higher in males compared to females, and in former compared to current or never smokers. There was no association of VFI with tumor histology or stage. A gene expression-based measure of tumor immunogenicity was negatively associated with VFI but had no bearing with BMI. Visceral obesity is appraisable in routine CT and can be an important correlate in lung cancer studies. |
| first_indexed | 2024-03-09T03:36:47Z |
| format | Article |
| id | doaj.art-b8bc9af11e424d6eb4ea565d768b3d84 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T03:36:47Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b8bc9af11e424d6eb4ea565d768b3d842023-12-03T14:47:50ZengMDPI AGCancers2072-66942022-07-011414345010.3390/cancers14143450Visceral Obesity in Non-Small Cell Lung CancerLindsay Nitsche0Yeshwanth Vedire1Eric Kannisto2Xiaolong Wang3Robert J. Seager4Sarabjot Pabla5Santosh K. Patnaik6Sai Yendamuri7Jacobs School of Medicine and Biomedical Sciences, State University of New York, 955 Main Street, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USAJacobs School of Medicine and Biomedical Sciences, State University of New York, 955 Main Street, Buffalo, NY 14263, USAOmniSeq, 700 Ellicott Street, Buffalo, NY 14263, USAOmniSeq, 700 Ellicott Street, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USAWhile obesity measured by body mass index (BMI) has been paradoxically associated with reduced risk and better outcome for lung cancer, recent studies suggest that the harm of obesity becomes apparent when measured as visceral adiposity. However, the prevalence of visceral obesity and its associations with demographic and tumor features are not established. We therefore conducted an observational study of visceral obesity in 994 non-small cell lung cancer (NSCLC) patients treated during 2008–2020 at our institution. Routine computerized tomography (CT) images of the patients, obtained within a year of tumor resection or biopsy, were used to measure cross-sectional abdominal fat areas. Important aspects of the measurement approach such as inter-observer variability and time stability were examined. Visceral obesity was semi-quantified as visceral fat index (VFI), the fraction of fat area that was visceral. VFI was found to be higher in males compared to females, and in former compared to current or never smokers. There was no association of VFI with tumor histology or stage. A gene expression-based measure of tumor immunogenicity was negatively associated with VFI but had no bearing with BMI. Visceral obesity is appraisable in routine CT and can be an important correlate in lung cancer studies.https://www.mdpi.com/2072-6694/14/14/3450adipositycomputerized tomographyepidemiologyimage analysislung cancerobesity |
| spellingShingle | Lindsay Nitsche Yeshwanth Vedire Eric Kannisto Xiaolong Wang Robert J. Seager Sarabjot Pabla Santosh K. Patnaik Sai Yendamuri Visceral Obesity in Non-Small Cell Lung Cancer Cancers adiposity computerized tomography epidemiology image analysis lung cancer obesity |
| title | Visceral Obesity in Non-Small Cell Lung Cancer |
| title_full | Visceral Obesity in Non-Small Cell Lung Cancer |
| title_fullStr | Visceral Obesity in Non-Small Cell Lung Cancer |
| title_full_unstemmed | Visceral Obesity in Non-Small Cell Lung Cancer |
| title_short | Visceral Obesity in Non-Small Cell Lung Cancer |
| title_sort | visceral obesity in non small cell lung cancer |
| topic | adiposity computerized tomography epidemiology image analysis lung cancer obesity |
| url | https://www.mdpi.com/2072-6694/14/14/3450 |
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