A comparison of aggregate p-value methods and multivariate statistics for self-contained tests of metabolic pathway analysis.

A comparison of aggregate p-value methods and multivariate statistics for self-contained tests of metabolic pathway analysis.

For pathway analysis of genomic data, the most common methods involve combining p-values from individual statistical tests. However, there are several multivariate statistical methods that can be used to test whether a pathway has changed. Because of the large number of variables and pathway sizes i...

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Bibliographic Details
Main Author: Matthew W Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4415974?pdf=render

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