Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case Report
Candiduria is a common nosocomial infection in hospitalized patients, which may progress into life-threatening candidemia. Successful treatment of urosepsis requires early and effective antifungal therapy, while the available agents within three pharmacological classes each have characteristic pharm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/10/800 |
| _version_ | 1797514197879226368 |
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| author | Zuzana Javorova Rihova Lubica Slobodova Anna Hrabovska |
| author_facet | Zuzana Javorova Rihova Lubica Slobodova Anna Hrabovska |
| author_sort | Zuzana Javorova Rihova |
| collection | DOAJ |
| description | Candiduria is a common nosocomial infection in hospitalized patients, which may progress into life-threatening candidemia. Successful treatment of urosepsis requires early and effective antifungal therapy, while the available agents within three pharmacological classes each have characteristic pharmacokinetics and side effect profiles. Moreover, treatment of <i>Candida</i> spp. infections is becoming challenging due to increasing multi drug-resistance. Here, we present a case of candidemia resulting from a multi drug-resistant <i>C. glabrata</i> infection of the urinary tract. Due to resistance to fluconazole and a contraindication for amphotericin B, micafungin was used in the treatment, regardless of its unfavorable pharmacokinetic properties. Our study showed that despite the expected low levels in the urinary tract, micafungin was successful in the eradication of <i>C. glabrata</i> allowing full recovery of the patient. Thus, micafungin should be considered in the management of urosepsis caused by sensitive <i>Candida</i> spp. |
| first_indexed | 2024-03-10T06:28:13Z |
| format | Article |
| id | doaj.art-b8c0cea07cc645a29fffc9f4dcc9951e |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T06:28:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b8c0cea07cc645a29fffc9f4dcc9951e2023-11-22T18:46:39ZengMDPI AGJournal of Fungi2309-608X2021-09-0171080010.3390/jof7100800Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case ReportZuzana Javorova Rihova0Lubica Slobodova1Anna Hrabovska2Department of Clinical Pharmacology, Teaching Hospital Trnava, A. Zarnova 11, 917 75 Trnava, SlovakiaDepartment of Pharmacology, Faculty of Medicine, Slovak Medical University in Bratislava, Limbova 12, 833 03 Bratislava, SlovakiaDepartment of Pharmacology, Faculty of Medicine, Slovak Medical University in Bratislava, Limbova 12, 833 03 Bratislava, SlovakiaCandiduria is a common nosocomial infection in hospitalized patients, which may progress into life-threatening candidemia. Successful treatment of urosepsis requires early and effective antifungal therapy, while the available agents within three pharmacological classes each have characteristic pharmacokinetics and side effect profiles. Moreover, treatment of <i>Candida</i> spp. infections is becoming challenging due to increasing multi drug-resistance. Here, we present a case of candidemia resulting from a multi drug-resistant <i>C. glabrata</i> infection of the urinary tract. Due to resistance to fluconazole and a contraindication for amphotericin B, micafungin was used in the treatment, regardless of its unfavorable pharmacokinetic properties. Our study showed that despite the expected low levels in the urinary tract, micafungin was successful in the eradication of <i>C. glabrata</i> allowing full recovery of the patient. Thus, micafungin should be considered in the management of urosepsis caused by sensitive <i>Candida</i> spp.https://www.mdpi.com/2309-608X/7/10/800urosepsiscandiduriacandidemia<i>Candida glabrata</i>micafunginechinocandins |
| spellingShingle | Zuzana Javorova Rihova Lubica Slobodova Anna Hrabovska Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case Report Journal of Fungi urosepsis candiduria candidemia <i>Candida glabrata</i> micafungin echinocandins |
| title | Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case Report |
| title_full | Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case Report |
| title_fullStr | Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case Report |
| title_full_unstemmed | Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case Report |
| title_short | Micafungin Is an Efficient Treatment of Multi Drug-Resistant <i>Candida glabrata</i> Urosepsis: A Case Report |
| title_sort | micafungin is an efficient treatment of multi drug resistant i candida glabrata i urosepsis a case report |
| topic | urosepsis candiduria candidemia <i>Candida glabrata</i> micafungin echinocandins |
| url | https://www.mdpi.com/2309-608X/7/10/800 |
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