Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity

Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity

Activity of c-AMP responsive element-binding protein (CREB) is decreased in Huntington’s disease (HD). Such decrease was also described by our group in the quinolinic acid lesion model of striatal excitotoxicity. The phosphodiesterase type IV inhibitor rolipram increases CREB phosphorylation. Such d...

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Bibliographic Details
Main Authors: Zena DeMarch, Carmela Giampà, Stefano Patassini, Alessandro Martorana, Giorgio Bernardi, Francesca Romana Fusco
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neurobiology of Disease
Subjects:
CREB
Huntington’s disease therapy
Quinolinic acid
Confocal microscopy
Basal ganglia
Rat
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002361

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http://www.sciencedirect.com/science/article/pii/S0969996106002361

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