Reward network dysfunction is associated with cognitive impairment after stroke
Stroke survivors not only suffer from severe motor, speech and neurocognitive deficits, but in many cases also from a “lack of pleasure” and a reduced motivational level. Especially apathy and anhedonic symptoms can be linked to a dysfunction of the reward system. Rewards are considered as important...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223001353 |
| _version_ | 1797806396075409408 |
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| author | Franziska Wagner Jenny Rogenz Laura Opitz Johanna Maas Alexander Schmidt Stefan Brodoehl Markus Ullsperger Carsten M. Klingner |
| author_facet | Franziska Wagner Jenny Rogenz Laura Opitz Johanna Maas Alexander Schmidt Stefan Brodoehl Markus Ullsperger Carsten M. Klingner |
| author_sort | Franziska Wagner |
| collection | DOAJ |
| description | Stroke survivors not only suffer from severe motor, speech and neurocognitive deficits, but in many cases also from a “lack of pleasure” and a reduced motivational level. Especially apathy and anhedonic symptoms can be linked to a dysfunction of the reward system. Rewards are considered as important co-factor for learning, so the question arises as to why and how this affects the rehabilitation of stroke patients.We investigated reward behaviour, learning ability and brain network connectivity in acute (3-7d) mild to moderate stroke patients (n = 28) and age-matched healthy controls (n = 26). Reward system activity was assessed using the Monetary Incentive Delay task (MID) during magnetoencephalography (MEG). Coherence analyses were used to demonstrate reward effects on brain functional network connectivity.The MID-task showed that stroke survivors had lower reward sensitivity and required greater monetary incentives to improve performance and showed deficits in learning improvement. MEG-analyses showed a reduced network connectivity in frontal and temporoparietal regions. All three effects (reduced reward sensitivity, reduced learning ability and altered cerebral connectivity) were found to be closely related and differed strongly from the healthy group.Our results reinforce the notion that acute stroke induces reward network dysfunction, leading to functional impairment of behavioural systems. These findings are representative of a general pattern in mild strokes and are independent of the specific lesion localisation. For stroke rehabilitation, these results represent an important point to identify the reduced learning capacity after stroke and to implement individualised recovery exercises accordingly. |
| first_indexed | 2024-03-13T06:06:39Z |
| format | Article |
| id | doaj.art-b8c4b1dbad794fefa46f512626273571 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-03-13T06:06:39Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-b8c4b1dbad794fefa46f5126262735712023-06-12T04:09:12ZengElsevierNeuroImage: Clinical2213-15822023-01-0139103446Reward network dysfunction is associated with cognitive impairment after strokeFranziska Wagner0Jenny Rogenz1Laura Opitz2Johanna Maas3Alexander Schmidt4Stefan Brodoehl5Markus Ullsperger6Carsten M. Klingner7Department of Neurology, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Biomagnetic Centre, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Corresponding author at: Clinic for Neurology, Jena University Hospital Friedrich Schiller University, Am Klinikum1, D 07747 Jena, Germany.Department of Neurology, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Biomagnetic Centre, 07747 Jena University Hospital, Friedrich Schiller University Jena, GermanyDepartment of Neurology, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Biomagnetic Centre, 07747 Jena University Hospital, Friedrich Schiller University Jena, GermanyDepartment of Neurology, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Biomagnetic Centre, 07747 Jena University Hospital, Friedrich Schiller University Jena, GermanyDepartment of Neurology, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Biomagnetic Centre, 07747 Jena University Hospital, Friedrich Schiller University Jena, GermanyDepartment of Neurology, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Biomagnetic Centre, 07747 Jena University Hospital, Friedrich Schiller University Jena, GermanyFaculty of Natural Sciences, Institute of Psychology, 39106 Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Otto-von-Guericke University Magdeburg, GermanyDepartment of Neurology, 07747 Jena University Hospital, Friedrich Schiller University Jena, Germany; Biomagnetic Centre, 07747 Jena University Hospital, Friedrich Schiller University Jena, GermanyStroke survivors not only suffer from severe motor, speech and neurocognitive deficits, but in many cases also from a “lack of pleasure” and a reduced motivational level. Especially apathy and anhedonic symptoms can be linked to a dysfunction of the reward system. Rewards are considered as important co-factor for learning, so the question arises as to why and how this affects the rehabilitation of stroke patients.We investigated reward behaviour, learning ability and brain network connectivity in acute (3-7d) mild to moderate stroke patients (n = 28) and age-matched healthy controls (n = 26). Reward system activity was assessed using the Monetary Incentive Delay task (MID) during magnetoencephalography (MEG). Coherence analyses were used to demonstrate reward effects on brain functional network connectivity.The MID-task showed that stroke survivors had lower reward sensitivity and required greater monetary incentives to improve performance and showed deficits in learning improvement. MEG-analyses showed a reduced network connectivity in frontal and temporoparietal regions. All three effects (reduced reward sensitivity, reduced learning ability and altered cerebral connectivity) were found to be closely related and differed strongly from the healthy group.Our results reinforce the notion that acute stroke induces reward network dysfunction, leading to functional impairment of behavioural systems. These findings are representative of a general pattern in mild strokes and are independent of the specific lesion localisation. For stroke rehabilitation, these results represent an important point to identify the reduced learning capacity after stroke and to implement individualised recovery exercises accordingly.http://www.sciencedirect.com/science/article/pii/S2213158223001353StrokeReward networkMEGFunctional connectivityCCN |
| spellingShingle | Franziska Wagner Jenny Rogenz Laura Opitz Johanna Maas Alexander Schmidt Stefan Brodoehl Markus Ullsperger Carsten M. Klingner Reward network dysfunction is associated with cognitive impairment after stroke NeuroImage: Clinical Stroke Reward network MEG Functional connectivity CCN |
| title | Reward network dysfunction is associated with cognitive impairment after stroke |
| title_full | Reward network dysfunction is associated with cognitive impairment after stroke |
| title_fullStr | Reward network dysfunction is associated with cognitive impairment after stroke |
| title_full_unstemmed | Reward network dysfunction is associated with cognitive impairment after stroke |
| title_short | Reward network dysfunction is associated with cognitive impairment after stroke |
| title_sort | reward network dysfunction is associated with cognitive impairment after stroke |
| topic | Stroke Reward network MEG Functional connectivity CCN |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223001353 |
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