The Role of Biomarkers in Surgery for Ulcerative Colitis: A Review
Ulcerative colitis (UC) is an inflammatory condition that generally affects the rectum and extends proximally into the colon in a continuous, distal-to-proximal pattern. Surgical resection (total proctocolectomy) is the only cure for UC and is often necessary in managing complicated or refractory di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/15/3362 |
| _version_ | 1797525468441739264 |
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| author | Jared Matson Sonia Ramamoorthy Nicole E. Lopez |
| author_facet | Jared Matson Sonia Ramamoorthy Nicole E. Lopez |
| author_sort | Jared Matson |
| collection | DOAJ |
| description | Ulcerative colitis (UC) is an inflammatory condition that generally affects the rectum and extends proximally into the colon in a continuous, distal-to-proximal pattern. Surgical resection (total proctocolectomy) is the only cure for UC and is often necessary in managing complicated or refractory disease. However, recent advances in biologically targeted therapies have resulted in improved disease control, and surgery is required in only a fraction of cases. This ever-increasing array of options for medical management has added complexity to surgical decision-making. In some circumstances, the added time required to ensure failure of medical therapy can delay colectomy in patients who will ultimately need it. Indeed, many patients with severe disease undergo trials of multiple medical therapies prior to considering surgery. In severe cases of UC, continued medical management has been associated with a delay to surgical intervention and higher rates of morbidity and mortality. Biomarkers represent a burgeoning field of research, particularly in inflammatory bowel disease and cancer. This review seeks to highlight the different possible settings for surgery in UC and the role various biomarkers might play in each. |
| first_indexed | 2024-03-10T09:13:17Z |
| format | Article |
| id | doaj.art-b8c605568f0343598739c95079d7d7bc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:13:17Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b8c605568f0343598739c95079d7d7bc2023-11-22T05:49:39ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011015336210.3390/jcm10153362The Role of Biomarkers in Surgery for Ulcerative Colitis: A ReviewJared Matson0Sonia Ramamoorthy1Nicole E. Lopez2Department of Surgery, UC San Diego, San Diego, CA 92037, USADepartment of Surgery, UC San Diego, San Diego, CA 92037, USADepartment of Surgery, UC San Diego, San Diego, CA 92037, USAUlcerative colitis (UC) is an inflammatory condition that generally affects the rectum and extends proximally into the colon in a continuous, distal-to-proximal pattern. Surgical resection (total proctocolectomy) is the only cure for UC and is often necessary in managing complicated or refractory disease. However, recent advances in biologically targeted therapies have resulted in improved disease control, and surgery is required in only a fraction of cases. This ever-increasing array of options for medical management has added complexity to surgical decision-making. In some circumstances, the added time required to ensure failure of medical therapy can delay colectomy in patients who will ultimately need it. Indeed, many patients with severe disease undergo trials of multiple medical therapies prior to considering surgery. In severe cases of UC, continued medical management has been associated with a delay to surgical intervention and higher rates of morbidity and mortality. Biomarkers represent a burgeoning field of research, particularly in inflammatory bowel disease and cancer. This review seeks to highlight the different possible settings for surgery in UC and the role various biomarkers might play in each.https://www.mdpi.com/2077-0383/10/15/3362biomarkersulcerative colitissurgeryinflammatory bowel diseasecolorectal surgery |
| spellingShingle | Jared Matson Sonia Ramamoorthy Nicole E. Lopez The Role of Biomarkers in Surgery for Ulcerative Colitis: A Review Journal of Clinical Medicine biomarkers ulcerative colitis surgery inflammatory bowel disease colorectal surgery |
| title | The Role of Biomarkers in Surgery for Ulcerative Colitis: A Review |
| title_full | The Role of Biomarkers in Surgery for Ulcerative Colitis: A Review |
| title_fullStr | The Role of Biomarkers in Surgery for Ulcerative Colitis: A Review |
| title_full_unstemmed | The Role of Biomarkers in Surgery for Ulcerative Colitis: A Review |
| title_short | The Role of Biomarkers in Surgery for Ulcerative Colitis: A Review |
| title_sort | role of biomarkers in surgery for ulcerative colitis a review |
| topic | biomarkers ulcerative colitis surgery inflammatory bowel disease colorectal surgery |
| url | https://www.mdpi.com/2077-0383/10/15/3362 |
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