A Novel Approach to Assess the Potency of Topical Corticosteroids
The potencies of topical corticosteroid products have mainly been classified using clinical data but in some instances, the US Food and Drug Administration’s (FDA’s) vasoconstrictor assay (VCA) to assess the skin blanching response has also been used. However, the reported skin blanching response da...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/9/1456 |
| _version_ | 1797517587596181504 |
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| author | Michael Zvidzayi Seeprarani Rath Charles Bon Sagaran Abboo Isadore Kanfer |
| author_facet | Michael Zvidzayi Seeprarani Rath Charles Bon Sagaran Abboo Isadore Kanfer |
| author_sort | Michael Zvidzayi |
| collection | DOAJ |
| description | The potencies of topical corticosteroid products have mainly been classified using clinical data but in some instances, the US Food and Drug Administration’s (FDA’s) vasoconstrictor assay (VCA) to assess the skin blanching response has also been used. However, the reported skin blanching response data were often based on a single visual reading and lack information on the dose (amount/quantity) or dose duration. Although several lists classifying potencies of various topical corticosteroid products have been published, the inherent potencies of topical corticosteroid raw materials used as active pharmaceutical ingredients (APIs) have not been investigated. The objective was to rank the inherent potencies of topical corticosteroid APIs and to standardize dosing such that the relevant compounds could be compared on a normalized molar basis. The potencies of clobetasol propionate, halcinonide, mometasone furoate, and fluocinolone acetonide were compared using the resulting <i>E<sub>max</sub></i> data following the fitting of the relevant response data to the <i>E<sub>max</sub></i> model where mometasone furoate > fluocinolone acetonide = clobetasol propionate > halcinonide. This ranking lists the respective inherent potencies of the APIs, which will facilitate the choice of a suitable candidate for incorporation into an appropriate topical corticosteroid product for a specific clinical indication. |
| first_indexed | 2024-03-10T07:18:36Z |
| format | Article |
| id | doaj.art-b8c60ca30fbe46bfa4be23975a3a34e4 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T07:18:36Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b8c60ca30fbe46bfa4be23975a3a34e42023-11-22T14:48:01ZengMDPI AGPharmaceutics1999-49232021-09-01139145610.3390/pharmaceutics13091456A Novel Approach to Assess the Potency of Topical CorticosteroidsMichael Zvidzayi0Seeprarani Rath1Charles Bon2Sagaran Abboo3Isadore Kanfer4Biopharmaceutics Research Institute, Rhodes University, Grahamstown 6139, South AfricaBiopharmaceutics Research Institute, Rhodes University, Grahamstown 6139, South AfricaBiostudy Solutions LLC, Wilmington, NC 28401, USAFaculty of Pharmacy, Rhodes University, Grahamstown 6139, South AfricaBiopharmaceutics Research Institute, Rhodes University, Grahamstown 6139, South AfricaThe potencies of topical corticosteroid products have mainly been classified using clinical data but in some instances, the US Food and Drug Administration’s (FDA’s) vasoconstrictor assay (VCA) to assess the skin blanching response has also been used. However, the reported skin blanching response data were often based on a single visual reading and lack information on the dose (amount/quantity) or dose duration. Although several lists classifying potencies of various topical corticosteroid products have been published, the inherent potencies of topical corticosteroid raw materials used as active pharmaceutical ingredients (APIs) have not been investigated. The objective was to rank the inherent potencies of topical corticosteroid APIs and to standardize dosing such that the relevant compounds could be compared on a normalized molar basis. The potencies of clobetasol propionate, halcinonide, mometasone furoate, and fluocinolone acetonide were compared using the resulting <i>E<sub>max</sub></i> data following the fitting of the relevant response data to the <i>E<sub>max</sub></i> model where mometasone furoate > fluocinolone acetonide = clobetasol propionate > halcinonide. This ranking lists the respective inherent potencies of the APIs, which will facilitate the choice of a suitable candidate for incorporation into an appropriate topical corticosteroid product for a specific clinical indication.https://www.mdpi.com/1999-4923/13/9/1456vasoconstrictor assayskin blanching responsechromametertopical corticosteroidsactive pharmaceutical ingredientspotency |
| spellingShingle | Michael Zvidzayi Seeprarani Rath Charles Bon Sagaran Abboo Isadore Kanfer A Novel Approach to Assess the Potency of Topical Corticosteroids Pharmaceutics vasoconstrictor assay skin blanching response chromameter topical corticosteroids active pharmaceutical ingredients potency |
| title | A Novel Approach to Assess the Potency of Topical Corticosteroids |
| title_full | A Novel Approach to Assess the Potency of Topical Corticosteroids |
| title_fullStr | A Novel Approach to Assess the Potency of Topical Corticosteroids |
| title_full_unstemmed | A Novel Approach to Assess the Potency of Topical Corticosteroids |
| title_short | A Novel Approach to Assess the Potency of Topical Corticosteroids |
| title_sort | novel approach to assess the potency of topical corticosteroids |
| topic | vasoconstrictor assay skin blanching response chromameter topical corticosteroids active pharmaceutical ingredients potency |
| url | https://www.mdpi.com/1999-4923/13/9/1456 |
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