Crosstalk between PI3 Kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK Pathways Downstream PDGF Receptor

Crosstalk between PI3 Kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK Pathways Downstream PDGF Receptor

Background/Aims: Our earlier studies suggested crosstalk between IRS/PI3 kinase/PDK1/Akt/Rac1/ROCK and (Shc2/Grb2/SOS)/Ras/Raf/MEK/ERK pathways downstream PDGF-ββ receptor responsible for chemotaxis and proliferation of malignant mesothelioma cells. The present study was conducted to obtain evidence...

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Bibliographic Details
Main Authors: Emma Tabe Eko Niba, Hisao Nagaya, Takeshi Kanno, Ayako Tsuchiya, Akinobu Gotoh, Chiharu Tabata, Kohzo Kuribayashi, Takashi Nakano, Tomoyuki Nishizaki
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Akt
Rac1
ERK
Crosstalk
PDGF-ββ receptor
Online Access:http://www.karger.com/Article/FullText/350108

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