Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze
In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals. Recently, they are interested in antidotes able not only to p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
2006-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/49/2/0113/ |
| _version_ | 1819038683746009088 |
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| author | Gabriela Kunešová Jiří Kassa |
| author_facet | Gabriela Kunešová Jiří Kassa |
| author_sort | Gabriela Kunešová |
| collection | DOAJ |
| description | In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals. Recently, they are interested in antidotes able not only to protect nerve agent-poisoned men from lethal toxic effects but also to improve their life quality by improvement of their central cognitive functions. In our study, the water maze was used to measure spatial working learning and memory in the case of tabun-induced cognitive impairment in albino Wistar rats. Antidotal treatment consisted of atropine alone or a combination of atropine with an oxime (obidoxime, trimedoxime or oxime HI-6). Our results suggest that atropine alone is not sufficient as a treatment for saving cognitive functions impaired by tabun. On the other hand, the addition of oxime to atropine contributes to improvement of cognitive performance in tabun-poisoned rats regardless of type of oxime. |
| first_indexed | 2024-12-21T08:41:13Z |
| format | Article |
| id | doaj.art-b8c942f0779a4dc59ccaa95027becb7d |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-21T08:41:13Z |
| publishDate | 2006-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-b8c942f0779a4dc59ccaa95027becb7d2022-12-21T19:09:57ZengKarolinum PressActa Medica1211-42861805-96942006-01-0149211311810.14712/18059694.2017.122Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water MazeGabriela Kunešová0Jiří Kassa1University of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Králové, Czech RepublicUniversity of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Králové, Czech RepublicIn the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals. Recently, they are interested in antidotes able not only to protect nerve agent-poisoned men from lethal toxic effects but also to improve their life quality by improvement of their central cognitive functions. In our study, the water maze was used to measure spatial working learning and memory in the case of tabun-induced cognitive impairment in albino Wistar rats. Antidotal treatment consisted of atropine alone or a combination of atropine with an oxime (obidoxime, trimedoxime or oxime HI-6). Our results suggest that atropine alone is not sufficient as a treatment for saving cognitive functions impaired by tabun. On the other hand, the addition of oxime to atropine contributes to improvement of cognitive performance in tabun-poisoned rats regardless of type of oxime.https://actamedica.lfhk.cuni.cz/49/2/0113/TabunWater mazeCognitive functionAtropineObidoximeTrimedoxime |
| spellingShingle | Gabriela Kunešová Jiří Kassa Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze Acta Medica Tabun Water maze Cognitive function Atropine Obidoxime Trimedoxime |
| title | Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze |
| title_full | Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze |
| title_fullStr | Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze |
| title_full_unstemmed | Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze |
| title_short | Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze |
| title_sort | comparison of effects of different antidotes on tabun induced cognitive impairment in rats using water maze |
| topic | Tabun Water maze Cognitive function Atropine Obidoxime Trimedoxime |
| url | https://actamedica.lfhk.cuni.cz/49/2/0113/ |
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