The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification
Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors....
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/7/2466 |
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| author | Yi-Chou Hou Chien-Lin Lu Cai-Mei Zheng Wen-Chih Liu Tzung-Hai Yen Ruei-Ming Chen Yuh-Feng Lin Chia-Ter Chao Kuo-Cheng Lu |
| author_facet | Yi-Chou Hou Chien-Lin Lu Cai-Mei Zheng Wen-Chih Liu Tzung-Hai Yen Ruei-Ming Chen Yuh-Feng Lin Chia-Ter Chao Kuo-Cheng Lu |
| author_sort | Yi-Chou Hou |
| collection | DOAJ |
| description | Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observations implied a role for mesenchymal stem cells and endothelial progenitor cells in vascular calcification. Mesenchymal stem cells reside in the bone marrow and the adventitial layer of arteries. Endothelial progenitor cells that originate from the bone marrow are an important mechanism for repairing injured endothelial cells. Mesenchymal stem cells may differentiate osteogenically by inflammation or by specific stimuli, which can activate calcification. However, the bioactive substances secreted from mesenchymal stem cells have been shown to mitigate vascular calcification by suppressing inflammation, bone morphogenetic protein 2, and the Wingless-INT signal. Vitamin D deficiency may contribute to vascular calcification. Vitamin D supplement has been used to modulate the osteoblastic differentiation of mesenchymal stem cells and to lessen vascular injury by stimulating adhesion and migration of endothelial progenitor cells. This narrative review clarifies the role of mesenchymal stem cells and the possible role of vitamin D in the mechanisms of vascular calcification. |
| first_indexed | 2024-03-10T20:44:12Z |
| format | Article |
| id | doaj.art-b8cb26edbfa04b42aec82a22e0573a94 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:44:12Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b8cb26edbfa04b42aec82a22e0573a942023-11-19T20:29:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01217246610.3390/ijms21072466The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular CalcificationYi-Chou Hou0Chien-Lin Lu1Cai-Mei Zheng2Wen-Chih Liu3Tzung-Hai Yen4Ruei-Ming Chen5Yuh-Feng Lin6Chia-Ter Chao7Kuo-Cheng Lu8Division of Nephrology, Department of Medicine, Cardinal-Tien Hospital, New Taipei City 231, TaiwanSchool of Medicine, Fu-Jen Catholic University, New Taipei City 234, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Toxicology, National Taiwan University College of Medicine, Taipei 104, TaiwanSchool of Medicine, Fu-Jen Catholic University, New Taipei City 234, TaiwanVascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observations implied a role for mesenchymal stem cells and endothelial progenitor cells in vascular calcification. Mesenchymal stem cells reside in the bone marrow and the adventitial layer of arteries. Endothelial progenitor cells that originate from the bone marrow are an important mechanism for repairing injured endothelial cells. Mesenchymal stem cells may differentiate osteogenically by inflammation or by specific stimuli, which can activate calcification. However, the bioactive substances secreted from mesenchymal stem cells have been shown to mitigate vascular calcification by suppressing inflammation, bone morphogenetic protein 2, and the Wingless-INT signal. Vitamin D deficiency may contribute to vascular calcification. Vitamin D supplement has been used to modulate the osteoblastic differentiation of mesenchymal stem cells and to lessen vascular injury by stimulating adhesion and migration of endothelial progenitor cells. This narrative review clarifies the role of mesenchymal stem cells and the possible role of vitamin D in the mechanisms of vascular calcification.https://www.mdpi.com/1422-0067/21/7/2466vascular calcificationvitamin Dmesenchymal stem cellendothelial progenitor cell |
| spellingShingle | Yi-Chou Hou Chien-Lin Lu Cai-Mei Zheng Wen-Chih Liu Tzung-Hai Yen Ruei-Ming Chen Yuh-Feng Lin Chia-Ter Chao Kuo-Cheng Lu The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification International Journal of Molecular Sciences vascular calcification vitamin D mesenchymal stem cell endothelial progenitor cell |
| title | The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification |
| title_full | The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification |
| title_fullStr | The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification |
| title_full_unstemmed | The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification |
| title_short | The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification |
| title_sort | role of vitamin d in modulating mesenchymal stem cells and endothelial progenitor cells for vascular calcification |
| topic | vascular calcification vitamin D mesenchymal stem cell endothelial progenitor cell |
| url | https://www.mdpi.com/1422-0067/21/7/2466 |
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