Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations
Aims: The aim of our study was to explore differences in genetic predisposition to obesity between the Hungarian general and Roma populations. Methods: A total of 1,152 samples from the Hungarian Roma population and 1,743 samples from the Hungarian general population were genotyped for 20 single nuc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-10-01
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| Series: | Obesity Facts |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/478094 |
| _version_ | 1828412703447711744 |
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| author | Károly Nagy Szilvia Fiatal János Sándor Róza Ádány |
| author_facet | Károly Nagy Szilvia Fiatal János Sándor Róza Ádány |
| author_sort | Károly Nagy |
| collection | DOAJ |
| description | Aims: The aim of our study was to explore differences in genetic predisposition to obesity between the Hungarian general and Roma populations. Methods: A total of 1,152 samples from the Hungarian Roma population and 1,743 samples from the Hungarian general population were genotyped for 20 single nucleotide polymorphisms (SNPs) associated with the risk of obesity. Two types of multilocus genetic risk scores were constructed to estimate the combined effect of selected SNPs. Results: Risk allele frequencies differed significantly between the two populations for 11 SNPs, with no enrichment in any of the two study groups. Variants (rs1558902, rs1121980, rs9939609, and rs9941349) in the fat mass and obesity-associated (FTO) gene exhibited strong but ethnicity-independent association with obesity. Genetic risk scores showed stronger associations with obesity in the Roma population compared with the Hungarian general population; however, without significant gene-population interaction. Conclusion: Differences in obesity prevalence between the Hungarian general and Hungarian Roma populations could not be explained by their distinct genetic susceptibility, rather by ethnicity-related environmental and behavioral factors. Nonetheless, particular gene-environment interactions might contribute to the distinct penetrance of the obesity-associated genetic factors in populations of different ethnic backgrounds. |
| first_indexed | 2024-12-10T12:54:35Z |
| format | Article |
| id | doaj.art-b8cd6174784e4e63b43b36f24877298a |
| institution | Directory Open Access Journal |
| issn | 1662-4025 1662-4033 |
| language | English |
| last_indexed | 2024-12-10T12:54:35Z |
| publishDate | 2017-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Obesity Facts |
| spelling | doaj.art-b8cd6174784e4e63b43b36f24877298a2022-12-22T01:48:08ZengKarger PublishersObesity Facts1662-40251662-40332017-10-0110544445710.1159/000478094478094Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma PopulationsKároly NagySzilvia FiatalJános SándorRóza ÁdányAims: The aim of our study was to explore differences in genetic predisposition to obesity between the Hungarian general and Roma populations. Methods: A total of 1,152 samples from the Hungarian Roma population and 1,743 samples from the Hungarian general population were genotyped for 20 single nucleotide polymorphisms (SNPs) associated with the risk of obesity. Two types of multilocus genetic risk scores were constructed to estimate the combined effect of selected SNPs. Results: Risk allele frequencies differed significantly between the two populations for 11 SNPs, with no enrichment in any of the two study groups. Variants (rs1558902, rs1121980, rs9939609, and rs9941349) in the fat mass and obesity-associated (FTO) gene exhibited strong but ethnicity-independent association with obesity. Genetic risk scores showed stronger associations with obesity in the Roma population compared with the Hungarian general population; however, without significant gene-population interaction. Conclusion: Differences in obesity prevalence between the Hungarian general and Hungarian Roma populations could not be explained by their distinct genetic susceptibility, rather by ethnicity-related environmental and behavioral factors. Nonetheless, particular gene-environment interactions might contribute to the distinct penetrance of the obesity-associated genetic factors in populations of different ethnic backgrounds.https://www.karger.com/Article/FullText/478094Body mass indexFTOGene variantsObesityRomaGypsyGenetic risk score |
| spellingShingle | Károly Nagy Szilvia Fiatal János Sándor Róza Ádány Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations Obesity Facts Body mass index FTO Gene variants Obesity Roma Gypsy Genetic risk score |
| title | Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations |
| title_full | Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations |
| title_fullStr | Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations |
| title_full_unstemmed | Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations |
| title_short | Distinct Penetrance of Obesity-Associated Susceptibility Alleles in the Hungarian General and Roma Populations |
| title_sort | distinct penetrance of obesity associated susceptibility alleles in the hungarian general and roma populations |
| topic | Body mass index FTO Gene variants Obesity Roma Gypsy Genetic risk score |
| url | https://www.karger.com/Article/FullText/478094 |
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