Bacterial clearance is improved in septic mice by platelet-activating factor-acetylhydrolase (PAF-AH) administration.

Bacterial clearance is improved in septic mice by platelet-activating factor-acetylhydrolase (PAF-AH) administration.

Current evidence indicates that dysregulation of the host inflammatory response to infectious agents is central to the mortality of patients with sepsis. Strategies to block inflammatory mediators such as PAF have been investigated as adjuvant therapies for sepsis. PAF-AH, the enzyme responsible for...

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Main Authors: Mariana G A Teixeira-da-Cunha, Rachel N Gomes, Nathassia Roehrs, Fernando A Bozza, Stephen M Prescott, Diana Stafforini, Guy A Zimmerman, Patricia T Bozza, Hugo C Castro-Faria-Neto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3771912?pdf=render

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