Prophylactic Antibiotics and Wound Infection
Introduction: Surgical site infections account for 14%-25% of all nosocomial infections. The main aims of this study were to audit the use of prophylactic antibiotic, to quantify the rate of post-operative wound infection, and to identify risk factors for its occurrence in general surgery. Meth...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3751/27-%206409_E(SH)_F(T)_PF1(Pr_P)_PFA(H).pdf |
| Summary: | Introduction: Surgical site infections account for 14%-25% of
all nosocomial infections. The main aims of this study were to
audit the use of prophylactic antibiotic, to quantify the rate of
post-operative wound infection, and to identify risk factors for its
occurrence in general surgery.
Methodology: A cross-sectional study was conducted in the
General Surgery Department in Khartoum Teaching Hospital–
Sudan. All Adult patients (age >18 years) admitted during March
1st to 31st October 2010 were recruited. Multivariable logistic
analysis was done to identify wound infection risk factors.
Prescriptions were audited against predetermined criteria.
Results: A total of 540 patients were recruited; (females73.7%
of total ). The performed surgical procedures were 547. The rate
of wound infection was 10.9%. Multivariable logistic analysis
showed that; ASA score > 3; (p= <0.001), wound class (p= 0.001),
and laparoscopic surgical technique; (p= 0.002) were significantly associated with prevalence of wound infection. Surgical
prophylaxis was unnecessarily given to 311 (97.5%) of 319
patients for whom it was not recommended. Prophylaxis was
recommended for 221 patients; of them 218 (98.6 %) were
given preoperative dose in the operating rooms. Evaluation of
prescriptions for those patients showed that; spectrum of antibiotic
was adequate for 160 (73.4%) patients, 143 (65.6%) were given
accurate doses, only 4 (1.8%) had the first preoperative dose/s
in proper time window, and for 186 (85.3%) of them prophylaxis
was extended post-operatively. Only 36 (6.7%) prescriptions
were found to be complying with the stated criteria.
Conclusion: The rate of wound infection was high and prophylactic antibiotics were irrationally used. Multiple interventions
are needed to correct the situation. |
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| ISSN: | 2249-782X 0973-709X |