Prophylactic Antibiotics and Wound Infection
Introduction: Surgical site infections account for 14%-25% of all nosocomial infections. The main aims of this study were to audit the use of prophylactic antibiotic, to quantify the rate of post-operative wound infection, and to identify risk factors for its occurrence in general surgery. Meth...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-12-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3751/27-%206409_E(SH)_F(T)_PF1(Pr_P)_PFA(H).pdf |
| _version_ | 1828757202618286080 |
|---|---|
| author | Abubaker Ibrahim Elbur Yousif M.A. Ahmed S.A. El-Sayed Manar E. Abdel-Rahman |
| author_facet | Abubaker Ibrahim Elbur Yousif M.A. Ahmed S.A. El-Sayed Manar E. Abdel-Rahman |
| author_sort | Abubaker Ibrahim Elbur |
| collection | DOAJ |
| description | Introduction: Surgical site infections account for 14%-25% of
all nosocomial infections. The main aims of this study were to
audit the use of prophylactic antibiotic, to quantify the rate of
post-operative wound infection, and to identify risk factors for its
occurrence in general surgery.
Methodology: A cross-sectional study was conducted in the
General Surgery Department in Khartoum Teaching Hospital–
Sudan. All Adult patients (age >18 years) admitted during March
1st to 31st October 2010 were recruited. Multivariable logistic
analysis was done to identify wound infection risk factors.
Prescriptions were audited against predetermined criteria.
Results: A total of 540 patients were recruited; (females73.7%
of total ). The performed surgical procedures were 547. The rate
of wound infection was 10.9%. Multivariable logistic analysis
showed that; ASA score > 3; (p= <0.001), wound class (p= 0.001),
and laparoscopic surgical technique; (p= 0.002) were significantly associated with prevalence of wound infection. Surgical
prophylaxis was unnecessarily given to 311 (97.5%) of 319
patients for whom it was not recommended. Prophylaxis was
recommended for 221 patients; of them 218 (98.6 %) were
given preoperative dose in the operating rooms. Evaluation of
prescriptions for those patients showed that; spectrum of antibiotic
was adequate for 160 (73.4%) patients, 143 (65.6%) were given
accurate doses, only 4 (1.8%) had the first preoperative dose/s
in proper time window, and for 186 (85.3%) of them prophylaxis
was extended post-operatively. Only 36 (6.7%) prescriptions
were found to be complying with the stated criteria.
Conclusion: The rate of wound infection was high and prophylactic antibiotics were irrationally used. Multiple interventions
are needed to correct the situation. |
| first_indexed | 2024-12-11T00:23:36Z |
| format | Article |
| id | doaj.art-b8cf88929e584c5b9c1be9439cd945eb |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T00:23:36Z |
| publishDate | 2013-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b8cf88929e584c5b9c1be9439cd945eb2022-12-22T01:27:39ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-12-017122747275110.7860/JCDR/2013/6409.3751Prophylactic Antibiotics and Wound InfectionAbubaker Ibrahim Elbur0Yousif M.A.1Ahmed S.A. El-Sayed2Manar E. Abdel-Rahman3Faculty, Pharmacy Practice Research Unit (PPRU), College of Pharmacy, Taif University, KSA.Professor, Pharmacy Practice Research Unit (PPRU), College of Pharmacy, Taif University, KSA. Faculty, Alshaab Teaching Hospital, Khartoum, Sudan.Faculty, Department of Statistics, Faculty of Mathematical Sciences, University of Khartoum, Sudan.Introduction: Surgical site infections account for 14%-25% of all nosocomial infections. The main aims of this study were to audit the use of prophylactic antibiotic, to quantify the rate of post-operative wound infection, and to identify risk factors for its occurrence in general surgery. Methodology: A cross-sectional study was conducted in the General Surgery Department in Khartoum Teaching Hospital– Sudan. All Adult patients (age >18 years) admitted during March 1st to 31st October 2010 were recruited. Multivariable logistic analysis was done to identify wound infection risk factors. Prescriptions were audited against predetermined criteria. Results: A total of 540 patients were recruited; (females73.7% of total ). The performed surgical procedures were 547. The rate of wound infection was 10.9%. Multivariable logistic analysis showed that; ASA score > 3; (p= <0.001), wound class (p= 0.001), and laparoscopic surgical technique; (p= 0.002) were significantly associated with prevalence of wound infection. Surgical prophylaxis was unnecessarily given to 311 (97.5%) of 319 patients for whom it was not recommended. Prophylaxis was recommended for 221 patients; of them 218 (98.6 %) were given preoperative dose in the operating rooms. Evaluation of prescriptions for those patients showed that; spectrum of antibiotic was adequate for 160 (73.4%) patients, 143 (65.6%) were given accurate doses, only 4 (1.8%) had the first preoperative dose/s in proper time window, and for 186 (85.3%) of them prophylaxis was extended post-operatively. Only 36 (6.7%) prescriptions were found to be complying with the stated criteria. Conclusion: The rate of wound infection was high and prophylactic antibiotics were irrationally used. Multiple interventions are needed to correct the situation.https://jcdr.net/articles/PDF/3751/27-%206409_E(SH)_F(T)_PF1(Pr_P)_PFA(H).pdfprophylactic antibioticswound infectionsudan |
| spellingShingle | Abubaker Ibrahim Elbur Yousif M.A. Ahmed S.A. El-Sayed Manar E. Abdel-Rahman Prophylactic Antibiotics and Wound Infection Journal of Clinical and Diagnostic Research prophylactic antibiotics wound infection sudan |
| title | Prophylactic Antibiotics and Wound Infection |
| title_full | Prophylactic Antibiotics and Wound Infection |
| title_fullStr | Prophylactic Antibiotics and Wound Infection |
| title_full_unstemmed | Prophylactic Antibiotics and Wound Infection |
| title_short | Prophylactic Antibiotics and Wound Infection |
| title_sort | prophylactic antibiotics and wound infection |
| topic | prophylactic antibiotics wound infection sudan |
| url | https://jcdr.net/articles/PDF/3751/27-%206409_E(SH)_F(T)_PF1(Pr_P)_PFA(H).pdf |
| work_keys_str_mv | AT abubakeribrahimelbur prophylacticantibioticsandwoundinfection AT yousifma prophylacticantibioticsandwoundinfection AT ahmedsaelsayed prophylacticantibioticsandwoundinfection AT manareabdelrahman prophylacticantibioticsandwoundinfection |