Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice)

Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice)

Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associated with Gancao via pregnane X receptor (PXR)-med...

Full description

Bibliographic Details
Main Authors:	Anqi Cheng, Saifei Lei, Junjie Zhu, Jie Lu, Mary F. Paine, Wen Xie, Xiaochao Ma
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2022-12-01
Series:	Liver Research
Subjects:	Gancao Licorice Glabridin Pregnane X receptor (PXR) Cytochrome P450 3A4 (CYP3A4) Herb-drug interactions
Online Access:	http://www.sciencedirect.com/science/article/pii/S254256842200068X

Similar Items

The effect of licorice drink on cytochrome P3A6 and P-glycoprotein gene transcription in rabbits
by: Rawia Al-Balawnih, et al.
Published: (2017-03-01)

Activation of PXR causes drug interactions with Paxlovid in transgenic mice
by: Saifei Lei, et al.
Published: (2023-11-01)

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation
by: Rebecca R. Florke Gee, et al.
Published: (2023-11-01)

SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells
by: Huasen Tan, et al.
Published: (2016-02-01)

Marine Ligands of the Pregnane X Receptor (PXR): An Overview
by: Alejandro Carazo, et al.
Published: (2019-09-01)

The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy
by: Danxin Wang, et al.
Published: (2012-10-01)

Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes
by: Dirk Theile, et al.
Published: (2021-05-01)

The role of pregnane X receptor (PXR) in substance metabolism
by: Ye Lv, et al.
Published: (2022-08-01)

Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation
by: Valentina Sepe, et al.
Published: (2014-05-01)

Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites
by: Rajamanikkam Kamaraj, et al.
Published: (2022-09-01)

Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian population?
by: Mohammed G. Maslub, et al.
Published: (2023-09-01)

Effects of the Licorice Isoflavans Licoricidin and Glabridin on the Growth, Adherence Properties, and Acid Production of <i>Streptococcus mutans</i>, and Assessment of Their Biocompatibility
by: Katy Vaillancourt, et al.
Published: (2021-02-01)

Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression
by: Siyun Xu, et al.
Published: (2014-10-01)

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library
by: Enni-Kaisa Mustonen, et al.
Published: (2022-04-01)

Metabolomic-based investigation of Yinlan alleviating hyperlipidemia by inhibiting blood stasis and phlegm turbidity through the PXR-CYP3A4-ABCB1-FXR pathway
by: Dongmei Li, et al.
Published: (2022-11-01)

CYP3A4 isoenzyme phenotyping for personalisation of pharmacotherapy
by: E. A. Egorenkov, et al.
Published: (2018-02-01)

Preparative Production of Functionalized (<i>N</i>- and <i>O</i>-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor
by: Matic Srdič, et al.
Published: (2022-01-01)

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by CYP3A4
by: Ilia G. Denisov, et al.
Published: (2022-06-01)

Acute and subacute oral toxicity assessment of Gancao Xiexin decoction in Sprague-Dawley rats
by: Li Ru, et al.
Published: (2023-01-01)

Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: An in vitro study
by: Megan E. Solan, et al.
Published: (2023-01-01)

Licorice (<i>Glycyrrhiza glabra</i>, <i>G. uralensis</i>, and <i>G. inflata</i>) and Their Constituents as Active Cosmeceutical Ingredients
by: Antonietta Cerulli, et al.
Published: (2022-01-01)

Effect of Pregnane X Receptor on <i>CYP3A29</i> Expression in Porcine Alveolar Macrophages during <i>Mycoplasma hyopneumoniae</i> Infection
by: Xiaoyang Yang, et al.
Published: (2021-01-01)

Impact of Pomegranate Juice on the Pharmacokinetics of CYP3A4- and CYP2C9-Mediated Drugs Metabolism: A Preclinical and Clinical Review
by: Kenza Mansoor, et al.
Published: (2023-02-01)

Water Exchange from the Buried Binding Sites of Cytochrome P450 Enzymes 1A2, 2D6, and 3A4 Correlates with Conformational Fluctuations
by: Olgun Guvench
Published: (2024-01-01)

Inhibitory effects of herbal medicines with claimed anticancer indications on cytochrome P450—An evaluation of drug-herb interactions risk
by: Misheck Mudyiwa, et al.
Published: (2023-09-01)

Atheroprotective Effects of <i>Glycyrrhiza glabra</i> L.
by: Yuliya V. Markina, et al.
Published: (2022-07-01)

Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib
by: Chumaphorn Rodseeda, et al.
Published: (2022-01-01)

In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes
by: Ning Zhang, et al.
Published: (2019-01-01)

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling
by: Laura Maria Fuhr, et al.
Published: (2022-07-01)

Loss of Protein Stability and Function Caused by P228L Variation in NADPH-Cytochrome P450 Reductase Linked to Lower Testosterone Levels
by: Maria Natalia Rojas Velazquez, et al.
Published: (2022-09-01)

Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship and Structure-Activity Relationship Models for Inhibitors and Non-inhibitors of Cytochrome P450 CYP3A4 and CYP2D6 Isozymes
by: Richard D. Beger, et al.
Published: (2012-03-01)

Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats
by: Dandan Liu, et al.
Published: (2023-04-01)

Corrigendum: Evaluation of herb–drug interaction between Danshen and rivaroxaban in rat and human liver microsomes
by: Xu Wang, et al.
Published: (2022-10-01)

Evaluation of Herb–Drug Interaction Between Danshen and Rivaroxaban in Rat and Human Liver Microsomes
by: Xu Wang, et al.
Published: (2022-07-01)

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach
by: Laura Maria Fuhr, et al.
Published: (2021-02-01)

Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates
by: Miriam Saiz-Rodríguez, et al.
Published: (2020-04-01)

The Impact of Single Nucleotide Polymorphisms on the Pharmacokinetics of Tacrolimus in Kidney Allograft Recipients of Northern-West, Iran
by: Elaheh Jabbari Hagh, et al.
Published: (2023-03-01)

A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators
by: Fatima Zahra Marok, et al.
Published: (2023-02-01)

Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment
by: Aikaterini Skandalaki, et al.
Published: (2021-08-01)

Mechanism of action of Shaoyao-Gancao decoction in relieving chronic inflammatory pain via Sema3G protein regulation in the dorsal root ganglion
by: Rong Lin, et al.
Published: (2024-01-01)