A Whole Exon Screening-Based Score Model Predicts Prognosis and Immune Checkpoint Inhibitor Therapy Effects in Low-Grade Glioma

A Whole Exon Screening-Based Score Model Predicts Prognosis and Immune Checkpoint Inhibitor Therapy Effects in Low-Grade Glioma

ObjectiveThis study aims to identify prognostic factors for low-grade glioma (LGG) via different machine learning methods in the whole genome and to predict patient prognoses based on these factors. We verified the results through in vitro experiments to further screen new potential therapeutic targ...

Full description

Bibliographic Details
Main Authors:	Cheng Luo, Songmao Wang, Wenjie Shan, Weijie Liao, Shikuan Zhang, Yanzhi Wang, Qilei Xin, Tingpeng Yang, Shaoliang Hu, Weidong Xie, Naihan Xu, Yaou Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Immunology
Subjects:	METTL7B PD-L1 prognosis prediction glioma m6A (N6-methyladenose) RNA stability
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.909189/full

Similar Items

Down-regulation of EPB41L4A-AS1 mediated the brain aging and neurodegenerative diseases via damaging synthesis of NAD+ and ATP
by: Tingpeng Yang, et al.
Published: (2021-11-01)

LINC00472 inhibits cell migration by enhancing intercellular adhesion and regulates H3K27ac level via interacting with P300 in renal clear cell carcinoma
by: Songmao Wang, et al.
Published: (2022-11-01)

Corrigendum for “LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2” [eBioMedicine 41 (2019) 200–213]
by: Meijian Liao, et al.
Published: (2024-04-01)

LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2Research in context
by: Meijian Liao, et al.
Published: (2019-03-01)

KAT8 promotes the proliferation of colorectal cancer cell lines by enhancing METTL3 expression
by: ZHANG Pengju, LI Jie, ZHANG Mengdi, SUN Shaoke, XU Yinzhe
Published: (2024-07-01)

Overexpression of lncRNA EPB41L4A-AS1 Induces Metabolic Reprogramming in Trophoblast Cells and Placenta Tissue of Miscarriage
by: Yuanchang Zhu, et al.
Published: (2025-03-01)

Overexpression of lncRNA EPB41L4A-AS1 Induces Metabolic Reprogramming in Trophoblast Cells and Placenta Tissue of Miscarriage
by: Yuanchang Zhu, et al.
Published: (2019-12-01)

m6A Methyltransferase METTL3 Promotes the Progression of Primary Acral Melanoma via Mediating TXNDC5 Methylation
by: Zhanghui Yue, et al.
Published: (2022-01-01)

Canagliflozin Delays Aging of HUVECs Induced by Palmitic Acid via the ROS/p38/JNK Pathway
by: Wenhui Hao, et al.
Published: (2023-03-01)

MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor
by: Xin Jiang, et al.
Published: (2017-07-01)

Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway
by: Yangyang Wang, et al.
Published: (2022-04-01)

RNA N6-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
by: Huarong Chen, et al.
Published: (2022-07-01)

MiR-181a regulates inflammation responses in monocytes and macrophages.
by: Weidong Xie, et al.
Published: (2013-01-01)

<i>SQSTM1/p62</i> Knockout by Using the CRISPR/Cas9 System Inhibits Migration and Invasion of Hepatocellular Carcinoma
by: Jinghua Lu, et al.
Published: (2023-04-01)

Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine
by: Guanhua Fang, et al.
Published: (2025-01-01)

Integrative analysis of m3C associated genes reveals METTL2A as a potential oncogene in breast Cancer
by: Shuai Wang, et al.
Published: (2022-10-01)

m6A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis
by: Junyu Zhai, et al.
Published: (2020-07-01)

METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling
by: Shuhua Luo, et al.
Published: (2023-03-01)

RNAs m6A modification facilitates UVB-induced photoaging
by: Shuping Zhang, et al.
Published: (2024-11-01)

METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m6A Dependent Manner
by: Jia Shi, et al.
Published: (2021-07-01)

Methodology of stable peptide based on propargylated sulfonium
by: Heng Li, et al.
Published: (2023-09-01)

The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF
by: Yingying Cheng, et al.
Published: (2020-08-01)

Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products
by: Yue Du, et al.
Published: (2022-04-01)

METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2
by: Yilin Guo, et al.
Published: (2024-10-01)

Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer
by: Min Wang, et al.
Published: (2020-08-01)

Comprehensive analysis of m6A modification in lipopolysaccharide-induced acute lung injury in mice
by: Chenzhen Xu, et al.
Published: (2024-01-01)

M6A methyltransferase METTL3 promotes glucose metabolism hub gene expression and induces metabolic dysfunction-associated steatotic liver disease (MASLD)
by: Shuowen Wang, et al.
Published: (2025-02-01)

Mettl14-mediated m6A modification is essential for visual function and retinal photoreceptor survival
by: Yeming Yang, et al.
Published: (2022-06-01)

Novel insights into the m6A-RNA methyltransferase METTL3 in cancer
by: Yiqing Cai, et al.
Published: (2021-04-01)

Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration
by: Liqi Shu, et al.
Published: (2021-10-01)

N 6-methyladenosine-modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing
by: Anqi Wang, et al.
Published: (2024-08-01)

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
by: Ben Yue, et al.
Published: (2019-10-01)

Prognostic Characteristics and Immune Effects of N6-Methyladenosine and 5-Methylcytosine-Related Regulatory Factors in Clear Cell Renal Cell Carcinoma
by: Lei Li, et al.
Published: (2022-04-01)

An Intelligent Nanoscale Insulin Delivery System
by: Wei Wang, et al.
Published: (2018-11-01)

The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway
by: Fuming Xie, et al.
Published: (2023-04-01)

Corrigendum: The m6A methyltransferase METTL16 inhibits the proliferation of pancreatic adenocarcinoma cancer cells via the p21 signaling pathway
by: Fuming Xie, et al.
Published: (2023-05-01)

METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma
by: Zhijin Zhang, et al.
Published: (2023-06-01)

N6-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis
by: Ding Ji, et al.
Published: (2023-04-01)

N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma
by: Yuanlei Chen, et al.
Published: (2022-05-01)

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease
by: Min Han, et al.
Published: (2020-02-01)