The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal Dissemination
Peritoneal dissemination is a disease that is difficult to treat surgically because it is widely scattered and proliferates in the abdominal cavity. It is a challenge that even if the drug is administered directly into the abdominal cavity, it rapidly disappears from the abdominal cavity, and the th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/5/252 |
| _version_ | 1797499727807250432 |
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| author | Ikumi Sugiyama Kaana Ando Yasuyuki Sadzuka |
| author_facet | Ikumi Sugiyama Kaana Ando Yasuyuki Sadzuka |
| author_sort | Ikumi Sugiyama |
| collection | DOAJ |
| description | Peritoneal dissemination is a disease that is difficult to treat surgically because it is widely scattered and proliferates in the abdominal cavity. It is a challenge that even if the drug is administered directly into the abdominal cavity, it rapidly disappears from the abdominal cavity, and the therapeutic effect is not optimal, as expected. In this study, for a liposomal paclitaxel in temperature-sensitive gel that is a suspension before administration and a gel after intraperitoneal administration, the antitumor effect of this formulation was evaluated. Temperature-sensitive gels were prepared using methylcellulose, sodium citrate, and macrogol 4000 and mixed with liposomal paclitaxel. Liposomal paclitaxel containing temperature-sensitive gel in the body was administered into the peritoneal cavity of a mouse model of peritoneal dissemination; the number of cells was significantly reduced compared to a paclitaxel solution of liposomal paclitaxel. These results showed that the liposome in temperature-sensitive gel inhibited cell proliferation in the abdominal cavity. This formulation can be administered easily at room temperature, and it gels and remains in the abdominal cavity for a long period, resulting in a more substantial effect than the existing drug. |
| first_indexed | 2024-03-10T03:51:34Z |
| format | Article |
| id | doaj.art-b8d1fd3c935a4704a4d9c36f75753675 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T03:51:34Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-b8d1fd3c935a4704a4d9c36f757536752023-11-23T11:04:36ZengMDPI AGGels2310-28612022-04-018525210.3390/gels8050252The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal DisseminationIkumi Sugiyama0Kaana Ando1Yasuyuki Sadzuka2Department of Advanced Pharmaceutics, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun 0208-3694, JapanPharmaceutical and Health Sciences, Graduate School of Pharmaceutical Science, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun 0208-3694, JapanDepartment of Advanced Pharmaceutics, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun 0208-3694, JapanPeritoneal dissemination is a disease that is difficult to treat surgically because it is widely scattered and proliferates in the abdominal cavity. It is a challenge that even if the drug is administered directly into the abdominal cavity, it rapidly disappears from the abdominal cavity, and the therapeutic effect is not optimal, as expected. In this study, for a liposomal paclitaxel in temperature-sensitive gel that is a suspension before administration and a gel after intraperitoneal administration, the antitumor effect of this formulation was evaluated. Temperature-sensitive gels were prepared using methylcellulose, sodium citrate, and macrogol 4000 and mixed with liposomal paclitaxel. Liposomal paclitaxel containing temperature-sensitive gel in the body was administered into the peritoneal cavity of a mouse model of peritoneal dissemination; the number of cells was significantly reduced compared to a paclitaxel solution of liposomal paclitaxel. These results showed that the liposome in temperature-sensitive gel inhibited cell proliferation in the abdominal cavity. This formulation can be administered easily at room temperature, and it gels and remains in the abdominal cavity for a long period, resulting in a more substantial effect than the existing drug.https://www.mdpi.com/2310-2861/8/5/252liposometemperature-sensitivegelationpaclitaxelperitoneal disseminationantitumor |
| spellingShingle | Ikumi Sugiyama Kaana Ando Yasuyuki Sadzuka The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal Dissemination Gels liposome temperature-sensitive gelation paclitaxel peritoneal dissemination antitumor |
| title | The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal Dissemination |
| title_full | The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal Dissemination |
| title_fullStr | The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal Dissemination |
| title_full_unstemmed | The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal Dissemination |
| title_short | The Basic Study of Liposome in Temperature-Sensitive Gel at Body Temperature for Treatment of Peritoneal Dissemination |
| title_sort | basic study of liposome in temperature sensitive gel at body temperature for treatment of peritoneal dissemination |
| topic | liposome temperature-sensitive gelation paclitaxel peritoneal dissemination antitumor |
| url | https://www.mdpi.com/2310-2861/8/5/252 |
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