Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite
Endothelial function is essential in the maintenance of systemic homeostasis, whose modulation strictly depends on the proper activity of tissue-specific angiocrine factors on the physiopathological mechanisms acting at both single and multi-organ levels. Several angiocrine factors take part in the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/6/5806 |
| _version_ | 1797611191851286528 |
|---|---|
| author | Giulia Querio Susanna Antoniotti Federica Geddo Renzo Levi Maria Pia Gallo |
| author_facet | Giulia Querio Susanna Antoniotti Federica Geddo Renzo Levi Maria Pia Gallo |
| author_sort | Giulia Querio |
| collection | DOAJ |
| description | Endothelial function is essential in the maintenance of systemic homeostasis, whose modulation strictly depends on the proper activity of tissue-specific angiocrine factors on the physiopathological mechanisms acting at both single and multi-organ levels. Several angiocrine factors take part in the vascular function itself by modulating vascular tone, inflammatory response, and thrombotic state. Recent evidence has outlined a strong relationship between endothelial factors and gut microbiota-derived molecules. In particular, the direct involvement of trimethylamine N-oxide (TMAO) in the development of endothelial dysfunction and its derived pathological outcomes, such as atherosclerosis, has come to light. Indeed, the role of TMAO in the modulation of factors strictly related to the development of endothelial dysfunction, such as nitric oxide, adhesion molecules (ICAM-1, VCAM-1, and selectins), and IL-6, has been widely accepted. The aim of this review is to present the latest studies that describe a direct role of TMAO in the modulation of angiocrine factors primarily involved in the development of vascular pathologies. |
| first_indexed | 2024-03-11T06:25:21Z |
| format | Article |
| id | doaj.art-b8d682733cee438a82799546d21e2177 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:25:21Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b8d682733cee438a82799546d21e21772023-11-17T11:39:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246580610.3390/ijms24065806Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived MetaboliteGiulia Querio0Susanna Antoniotti1Federica Geddo2Renzo Levi3Maria Pia Gallo4Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, ItalyEndothelial function is essential in the maintenance of systemic homeostasis, whose modulation strictly depends on the proper activity of tissue-specific angiocrine factors on the physiopathological mechanisms acting at both single and multi-organ levels. Several angiocrine factors take part in the vascular function itself by modulating vascular tone, inflammatory response, and thrombotic state. Recent evidence has outlined a strong relationship between endothelial factors and gut microbiota-derived molecules. In particular, the direct involvement of trimethylamine N-oxide (TMAO) in the development of endothelial dysfunction and its derived pathological outcomes, such as atherosclerosis, has come to light. Indeed, the role of TMAO in the modulation of factors strictly related to the development of endothelial dysfunction, such as nitric oxide, adhesion molecules (ICAM-1, VCAM-1, and selectins), and IL-6, has been widely accepted. The aim of this review is to present the latest studies that describe a direct role of TMAO in the modulation of angiocrine factors primarily involved in the development of vascular pathologies.https://www.mdpi.com/1422-0067/24/6/5806endotheliumvascular functionangiocrine factorsTMAOgut microbiota |
| spellingShingle | Giulia Querio Susanna Antoniotti Federica Geddo Renzo Levi Maria Pia Gallo Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite International Journal of Molecular Sciences endothelium vascular function angiocrine factors TMAO gut microbiota |
| title | Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite |
| title_full | Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite |
| title_fullStr | Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite |
| title_full_unstemmed | Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite |
| title_short | Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite |
| title_sort | modulation of endothelial function by tmao a gut microbiota derived metabolite |
| topic | endothelium vascular function angiocrine factors TMAO gut microbiota |
| url | https://www.mdpi.com/1422-0067/24/6/5806 |
| work_keys_str_mv | AT giuliaquerio modulationofendothelialfunctionbytmaoagutmicrobiotaderivedmetabolite AT susannaantoniotti modulationofendothelialfunctionbytmaoagutmicrobiotaderivedmetabolite AT federicageddo modulationofendothelialfunctionbytmaoagutmicrobiotaderivedmetabolite AT renzolevi modulationofendothelialfunctionbytmaoagutmicrobiotaderivedmetabolite AT mariapiagallo modulationofendothelialfunctionbytmaoagutmicrobiotaderivedmetabolite |