Cardiac Connexin-43 Hemichannels and Pannexin1 Channels: Provocative Antiarrhythmic Targets

Cardiac Connexin-43 Hemichannels and Pannexin1 Channels: Provocative Antiarrhythmic Targets

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal caveolae/rafts compartments. GJCs are fundamental for the direct cardiac cell-to-cell transmission of electrical and molecular sign...

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Bibliographic Details
Main Authors: Katarina Andelova, Tamara Egan Benova, Barbara Szeiffova Bacova, Matus Sykora, Natalia Jorgelina Prado, Emiliano Raul Diez, Peter Hlivak, Narcis Tribulova
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
cardiac arrhythmias
Cx43 hemi-channels
pannexin1 channels
mimetic peptides
cardio-protection
Online Access:https://www.mdpi.com/1422-0067/22/1/260

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