Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier
In this work, the size transformation of the TiO<sub>2</sub> nanofraction from pharmaceutical grade E171 powder was studied during its transit through the gastrointestinal tract (GIT). It was shown that pharmaceutical-grade TiO<sub>2</sub> powder contained about 0.68% (<i&...
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2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| author | M. S. Ryabtseva S. F. Umanskaya M. A. Shevchenko V. S. Krivobok A. V. Kolobov A. A. Nastulyavichus S. I. Chentsov V. D. Sibirtsev |
| author_facet | M. S. Ryabtseva S. F. Umanskaya M. A. Shevchenko V. S. Krivobok A. V. Kolobov A. A. Nastulyavichus S. I. Chentsov V. D. Sibirtsev |
| author_sort | M. S. Ryabtseva |
| collection | DOAJ |
| description | In this work, the size transformation of the TiO<sub>2</sub> nanofraction from pharmaceutical grade E171 powder was studied during its transit through the gastrointestinal tract (GIT). It was shown that pharmaceutical-grade TiO<sub>2</sub> powder contained about 0.68% (<i>w</i>/<i>w</i>) of particles smaller than 240 nm in diameter. In the observed GIT transit process the TiO<sub>2</sub> nanoparticles were agglomerated up to 150–200 nm in simulated salivary fluid, with gradual agglomerate enlargement up to 300–600 nm and more than 1 micron in simulated gastric fluid. In the intestinal fluid the reverse process occurred, involving a decrease of agglomerates accompanied by the formation of a small fraction with ~50 nm average size. This fraction can be further involved in the histohematic transport process. The acidity degree (pH) and mineral composition of solutions, as well as the transit speed along the gastrointestinal tract, influence the nature of the particle transformation significantly. The rapid passing between the gastrointestinal tract sections creates conditions for a decrease in part of the TiO<sub>2</sub> particles, up to 100 nm, and may be associated with the violation of the structural and functional integrity of the intestinal mucus layer. |
| first_indexed | 2024-03-10T21:43:03Z |
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| id | doaj.art-b8d8a534776d4c56b372ee7cf2888c2a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:03Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b8d8a534776d4c56b372ee7cf2888c2a2023-11-19T14:32:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124191491110.3390/ijms241914911Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal BarrierM. S. Ryabtseva0S. F. Umanskaya1M. A. Shevchenko2V. S. Krivobok3A. V. Kolobov4A. A. Nastulyavichus5S. I. Chentsov6V. D. Sibirtsev7P. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky Prospect 53, Moscow 119991, RussiaP. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky Prospect 53, Moscow 119991, RussiaP. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky Prospect 53, Moscow 119991, RussiaP. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky Prospect 53, Moscow 119991, RussiaP. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky Prospect 53, Moscow 119991, RussiaP. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky Prospect 53, Moscow 119991, RussiaP. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninsky Prospect 53, Moscow 119991, RussiaDepartment of Veterinary Medicine, Institute of Veterinary, Veterinary-Sanitary Examination and Agricultural Safety, Russian Biotechnological University, Volokolamskoe Highway 11, Moscow 125080, RussiaIn this work, the size transformation of the TiO<sub>2</sub> nanofraction from pharmaceutical grade E171 powder was studied during its transit through the gastrointestinal tract (GIT). It was shown that pharmaceutical-grade TiO<sub>2</sub> powder contained about 0.68% (<i>w</i>/<i>w</i>) of particles smaller than 240 nm in diameter. In the observed GIT transit process the TiO<sub>2</sub> nanoparticles were agglomerated up to 150–200 nm in simulated salivary fluid, with gradual agglomerate enlargement up to 300–600 nm and more than 1 micron in simulated gastric fluid. In the intestinal fluid the reverse process occurred, involving a decrease of agglomerates accompanied by the formation of a small fraction with ~50 nm average size. This fraction can be further involved in the histohematic transport process. The acidity degree (pH) and mineral composition of solutions, as well as the transit speed along the gastrointestinal tract, influence the nature of the particle transformation significantly. The rapid passing between the gastrointestinal tract sections creates conditions for a decrease in part of the TiO<sub>2</sub> particles, up to 100 nm, and may be associated with the violation of the structural and functional integrity of the intestinal mucus layer.https://www.mdpi.com/1422-0067/24/19/14911nanotechnologynanoparticlestitanium dioxidegastrointestinal tracthistohematic transport |
| spellingShingle | M. S. Ryabtseva S. F. Umanskaya M. A. Shevchenko V. S. Krivobok A. V. Kolobov A. A. Nastulyavichus S. I. Chentsov V. D. Sibirtsev Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier International Journal of Molecular Sciences nanotechnology nanoparticles titanium dioxide gastrointestinal tract histohematic transport |
| title | Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier |
| title_full | Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier |
| title_fullStr | Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier |
| title_full_unstemmed | Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier |
| title_short | Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier |
| title_sort | transformation of nano size titanium dioxide particles in the gastrointestinal tract and its role in the transfer of nanoparticles through the intestinal barrier |
| topic | nanotechnology nanoparticles titanium dioxide gastrointestinal tract histohematic transport |
| url | https://www.mdpi.com/1422-0067/24/19/14911 |
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