Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice
Dll4/Notch1 signal promotes the progression of HCC, while Jag1/Notch2 signal antagonistically suppresses it in murine chemical hepatocarcinogenesis. Nakano et al. report that two distinct Notch signals regulate the progression of hepatocellular carcinoma (HCC) using tissue specific loss of function...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03013-8 |
| _version_ | 1819260937890168832 |
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| author | Yasuhiro Nakano Sachie Nakao Minako Sueoka Daigo Kasahara Yuri Tanno Hideaki Sumiyoshi Tohru Itoh Atsushi Miyajima Katsuto Hozumi Yutaka Inagaki |
| author_facet | Yasuhiro Nakano Sachie Nakao Minako Sueoka Daigo Kasahara Yuri Tanno Hideaki Sumiyoshi Tohru Itoh Atsushi Miyajima Katsuto Hozumi Yutaka Inagaki |
| author_sort | Yasuhiro Nakano |
| collection | DOAJ |
| description | Dll4/Notch1 signal promotes the progression of HCC, while Jag1/Notch2 signal antagonistically suppresses it in murine chemical hepatocarcinogenesis. Nakano et al. report that two distinct Notch signals regulate the progression of hepatocellular carcinoma (HCC) using tissue specific loss of function mouse mutants. They find Dll4/Notch1 signal promotes HCC progression, while the Jag1/Notch2 signal antagonistically suppresses it. |
| first_indexed | 2024-12-23T19:33:51Z |
| format | Article |
| id | doaj.art-b8d8d5deaba64e4cbc50de2a16ed8551 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-23T19:33:51Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-b8d8d5deaba64e4cbc50de2a16ed85512022-12-21T17:33:50ZengNature PortfolioCommunications Biology2399-36422022-01-015111010.1038/s42003-022-03013-8Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in miceYasuhiro Nakano0Sachie Nakao1Minako Sueoka2Daigo Kasahara3Yuri Tanno4Hideaki Sumiyoshi5Tohru Itoh6Atsushi Miyajima7Katsuto Hozumi8Yutaka Inagaki9Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai UniversityCenter for Matrix Biology and Medicine, Graduate School of Medicine, Tokai UniversityDepartment of Innovative Medical Science, Tokai University School of MedicineCenter for Matrix Biology and Medicine, Graduate School of Medicine, Tokai UniversityDepartment of Innovative Medical Science, Tokai University School of MedicineCenter for Matrix Biology and Medicine, Graduate School of Medicine, Tokai UniversityLaboratory of Cell Growth and Differentiation, Institute for Quantitative Biosciences, The University of TokyoLaboratory of Cell Growth and Differentiation, Institute for Quantitative Biosciences, The University of TokyoCenter for Matrix Biology and Medicine, Graduate School of Medicine, Tokai UniversityCenter for Matrix Biology and Medicine, Graduate School of Medicine, Tokai UniversityDll4/Notch1 signal promotes the progression of HCC, while Jag1/Notch2 signal antagonistically suppresses it in murine chemical hepatocarcinogenesis. Nakano et al. report that two distinct Notch signals regulate the progression of hepatocellular carcinoma (HCC) using tissue specific loss of function mouse mutants. They find Dll4/Notch1 signal promotes HCC progression, while the Jag1/Notch2 signal antagonistically suppresses it.https://doi.org/10.1038/s42003-022-03013-8 |
| spellingShingle | Yasuhiro Nakano Sachie Nakao Minako Sueoka Daigo Kasahara Yuri Tanno Hideaki Sumiyoshi Tohru Itoh Atsushi Miyajima Katsuto Hozumi Yutaka Inagaki Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice Communications Biology |
| title | Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice |
| title_full | Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice |
| title_fullStr | Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice |
| title_full_unstemmed | Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice |
| title_short | Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice |
| title_sort | two distinct notch signals delta like 4 notch1 and jagged 1 notch2 antagonistically regulate chemical hepatocarcinogenesis in mice |
| url | https://doi.org/10.1038/s42003-022-03013-8 |
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