Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil
Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery. In this work, we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-03-01
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| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022001537 |
| _version_ | 1797705074598739968 |
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| author | Lina Tao Panpan Wang Ting Zhang Mengzhen Ding Lijie Liu Ningping Tao Xichang Wang Jian Zhong |
| author_facet | Lina Tao Panpan Wang Ting Zhang Mengzhen Ding Lijie Liu Ningping Tao Xichang Wang Jian Zhong |
| author_sort | Lina Tao |
| collection | DOAJ |
| description | Specific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery. In this work, we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil. The spherical capsules had diameters from 2.05 mm to 0.35 mm with the increased applied voltages. The capsules consisted of uniform (at applied voltages of ≤ 10 kV) or nonuniform (at applied voltages of > 10 kV) multicores. The obtained capsules had reasonable loading ratios (9.7 %−6.3 %) due to the multicore structure. In addition, the obtained capsules had specific and sustained release behaviors of fish oil into the small intestinal phase of in vitro gastrointestinal tract and small intestinal tract models. The simple monoaxial dispersion electrospraying-ionotropic gelatin technique does not involve complicated preparation formulations and polymer modification, which makes the technique has a potential application prospect for the fish oil preparations and the encapsulation of functional active substances in the field of food and drug industries. |
| first_indexed | 2024-03-12T05:29:57Z |
| format | Article |
| id | doaj.art-b8d9547376fd4da7bf99fa22eccc36d3 |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T05:29:57Z |
| publishDate | 2023-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-b8d9547376fd4da7bf99fa22eccc36d32023-09-03T06:57:44ZengTsinghua University PressFood Science and Human Wellness2213-45302023-03-01122397406Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish OilLina Tao0Panpan Wang1Ting Zhang2Mengzhen Ding3Lijie Liu4Ningping Tao5Xichang Wang6Jian Zhong7National R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaNational R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaNational R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaNational R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaNational R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaNational R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaNational R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaCorresponding author at: College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China.; National R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, ChinaSpecific and sustained release of nutrients from capsules to the gastrointestinal tract has attracted many attentions in the field of food and drug delivery. In this work, we reported a monoaxial dispersion electrospraying-ionotropic gelation technique to prepare multicore millimeter-sized spherical capsules for specific and sustained release of fish oil. The spherical capsules had diameters from 2.05 mm to 0.35 mm with the increased applied voltages. The capsules consisted of uniform (at applied voltages of ≤ 10 kV) or nonuniform (at applied voltages of > 10 kV) multicores. The obtained capsules had reasonable loading ratios (9.7 %−6.3 %) due to the multicore structure. In addition, the obtained capsules had specific and sustained release behaviors of fish oil into the small intestinal phase of in vitro gastrointestinal tract and small intestinal tract models. The simple monoaxial dispersion electrospraying-ionotropic gelatin technique does not involve complicated preparation formulations and polymer modification, which makes the technique has a potential application prospect for the fish oil preparations and the encapsulation of functional active substances in the field of food and drug industries.http://www.sciencedirect.com/science/article/pii/S2213453022001537Ionotropic gelationMillimeter-sized spherical capsuleMonoaxial dispersion electrosprayingMulticoreSpecific and sustained release |
| spellingShingle | Lina Tao Panpan Wang Ting Zhang Mengzhen Ding Lijie Liu Ningping Tao Xichang Wang Jian Zhong Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil Food Science and Human Wellness Ionotropic gelation Millimeter-sized spherical capsule Monoaxial dispersion electrospraying Multicore Specific and sustained release |
| title | Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil |
| title_full | Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil |
| title_fullStr | Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil |
| title_full_unstemmed | Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil |
| title_short | Preparation of Multicore Millimeter-Sized Spherical Alginate Capsules to Specifically and Sustainedly Release Fish Oil |
| title_sort | preparation of multicore millimeter sized spherical alginate capsules to specifically and sustainedly release fish oil |
| topic | Ionotropic gelation Millimeter-sized spherical capsule Monoaxial dispersion electrospraying Multicore Specific and sustained release |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022001537 |
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