Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering
The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in this rapidly growing field. We will restrict ours...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-09-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209008 |
| _version_ | 1818281946411696128 |
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| author | Rajni Verma Ulrich Schwaneberg Danilo Roccatano |
| author_facet | Rajni Verma Ulrich Schwaneberg Danilo Roccatano |
| author_sort | Rajni Verma |
| collection | DOAJ |
| description | The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in this rapidly growing field. We will restrict ourselves to overview the availability, usability and limitations of web servers, databases and other computational tools proposed in the last five years. The goal of this review is to provide concise information about currently available computational resources to assist the design of directed evolution based protein engineering experiment. |
| first_indexed | 2024-12-13T00:13:12Z |
| format | Article |
| id | doaj.art-b8db5856bda4442eadc80aeb9ab4ac15 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-13T00:13:12Z |
| publishDate | 2012-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-b8db5856bda4442eadc80aeb9ab4ac152022-12-22T00:05:53ZengElsevierComputational and Structural Biotechnology Journal2001-03702012-09-0123e201209008Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein EngineeringRajni VermaUlrich SchwanebergDanilo RoccatanoThe combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in this rapidly growing field. We will restrict ourselves to overview the availability, usability and limitations of web servers, databases and other computational tools proposed in the last five years. The goal of this review is to provide concise information about currently available computational resources to assist the design of directed evolution based protein engineering experiment.http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209008directed evolutionrational designsemi-rational designdiversity generationfocused librarymutational effect |
| spellingShingle | Rajni Verma Ulrich Schwaneberg Danilo Roccatano Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering Computational and Structural Biotechnology Journal directed evolution rational design semi-rational design diversity generation focused library mutational effect |
| title | Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering |
| title_full | Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering |
| title_fullStr | Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering |
| title_full_unstemmed | Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering |
| title_short | Computer-Aided Protein Directed Evolution: a Review of Web Servers, Databases and other Computational Tools for Protein Engineering |
| title_sort | computer aided protein directed evolution a review of web servers databases and other computational tools for protein engineering |
| topic | directed evolution rational design semi-rational design diversity generation focused library mutational effect |
| url | http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209008 |
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