Molecular Mechanisms and Current Treatment Options for Cancer Cachexia
Cancer cachexia is a condition marked by functional, metabolic, and immunological dysfunctions associated with skeletal muscle (SM) atrophy, adipose tissue loss, fat reduction, systemic inflammation, and anorexia. Generally, the condition is caused by a variety of mediators produced by cancer cells...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/9/2107 |
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| author | Syed Sayeed Ahmad Khurshid Ahmad Sibhghatulla Shaikh Hye Jin You Eun-Young Lee Shahid Ali Eun Ju Lee Inho Choi |
| author_facet | Syed Sayeed Ahmad Khurshid Ahmad Sibhghatulla Shaikh Hye Jin You Eun-Young Lee Shahid Ali Eun Ju Lee Inho Choi |
| author_sort | Syed Sayeed Ahmad |
| collection | DOAJ |
| description | Cancer cachexia is a condition marked by functional, metabolic, and immunological dysfunctions associated with skeletal muscle (SM) atrophy, adipose tissue loss, fat reduction, systemic inflammation, and anorexia. Generally, the condition is caused by a variety of mediators produced by cancer cells and cells in tumor microenvironments. Myostatin and activin signaling, IGF-1/PI3K/AKT signaling, and JAK-STAT signaling are known to play roles in cachexia, and thus, these pathways are considered potential therapeutic targets. This review discusses the current state of knowledge of the molecular mechanisms underlying cachexia and the available therapeutic options and was undertaken to increase understanding of the various factors/pathways/mediators involved and to identify potential treatment options. |
| first_indexed | 2024-03-10T04:19:17Z |
| format | Article |
| id | doaj.art-b8db7731917540869a3c279632ef7bfb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:19:17Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b8db7731917540869a3c279632ef7bfb2023-11-23T07:54:55ZengMDPI AGCancers2072-66942022-04-01149210710.3390/cancers14092107Molecular Mechanisms and Current Treatment Options for Cancer CachexiaSyed Sayeed Ahmad0Khurshid Ahmad1Sibhghatulla Shaikh2Hye Jin You3Eun-Young Lee4Shahid Ali5Eun Ju Lee6Inho Choi7Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, KoreaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, KoreaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, KoreaTumor Microenvironment Branch, Division of Cancer Biology, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Gyeonggi-do, KoreaTumor Microenvironment Branch, Division of Cancer Biology, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Gyeonggi-do, KoreaResearch Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, KoreaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, KoreaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, KoreaCancer cachexia is a condition marked by functional, metabolic, and immunological dysfunctions associated with skeletal muscle (SM) atrophy, adipose tissue loss, fat reduction, systemic inflammation, and anorexia. Generally, the condition is caused by a variety of mediators produced by cancer cells and cells in tumor microenvironments. Myostatin and activin signaling, IGF-1/PI3K/AKT signaling, and JAK-STAT signaling are known to play roles in cachexia, and thus, these pathways are considered potential therapeutic targets. This review discusses the current state of knowledge of the molecular mechanisms underlying cachexia and the available therapeutic options and was undertaken to increase understanding of the various factors/pathways/mediators involved and to identify potential treatment options.https://www.mdpi.com/2072-6694/14/9/2107cancer cachexiaskeletal muscleinhibitorsmyostatinnatural compounds |
| spellingShingle | Syed Sayeed Ahmad Khurshid Ahmad Sibhghatulla Shaikh Hye Jin You Eun-Young Lee Shahid Ali Eun Ju Lee Inho Choi Molecular Mechanisms and Current Treatment Options for Cancer Cachexia Cancers cancer cachexia skeletal muscle inhibitors myostatin natural compounds |
| title | Molecular Mechanisms and Current Treatment Options for Cancer Cachexia |
| title_full | Molecular Mechanisms and Current Treatment Options for Cancer Cachexia |
| title_fullStr | Molecular Mechanisms and Current Treatment Options for Cancer Cachexia |
| title_full_unstemmed | Molecular Mechanisms and Current Treatment Options for Cancer Cachexia |
| title_short | Molecular Mechanisms and Current Treatment Options for Cancer Cachexia |
| title_sort | molecular mechanisms and current treatment options for cancer cachexia |
| topic | cancer cachexia skeletal muscle inhibitors myostatin natural compounds |
| url | https://www.mdpi.com/2072-6694/14/9/2107 |
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