Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia
Nonocclusive mesenteric ischemia (NOMI) is induced by intestinal vasospasm without thromboembolic occlusion and is associated with high morbidity and mortality. The estimated overall incidence of autopsy-verified fatal NOMI is 2.0 cases/100,000 person-years; however, no pediatric or adolescent cases...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-02-01
|
| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187595721400165X |
| _version_ | 1818999134790615040 |
|---|---|
| author | Koichi Hirabayashi Mitsuho Takatsuki Mitsuo Motobayashi Takashi Kurata Shoji Saito Tomonari Shigemura Yozo Nakazawa Kazuo Sakashita Satoshi Ishizone Hiroyoshi Ota Kenichi Koike |
| author_facet | Koichi Hirabayashi Mitsuho Takatsuki Mitsuo Motobayashi Takashi Kurata Shoji Saito Tomonari Shigemura Yozo Nakazawa Kazuo Sakashita Satoshi Ishizone Hiroyoshi Ota Kenichi Koike |
| author_sort | Koichi Hirabayashi |
| collection | DOAJ |
| description | Nonocclusive mesenteric ischemia (NOMI) is induced by intestinal vasospasm without thromboembolic occlusion and is associated with high morbidity and mortality. The estimated overall incidence of autopsy-verified fatal NOMI is 2.0 cases/100,000 person-years; however, no pediatric or adolescent cases have yet been reported. An 18-year-old female was diagnosed with B-cell precursor acute lymphoblastic leukemia at the age of 10 years. Our patient received three allogeneic hematopoietic stem cell transplantations but experienced hematological relapse after each. She received combination therapy of prednisolone, L-asparaginase, vincristine, and bortezomib after the third relapse. On Day 16 after the initiation of chemotherapy, she developed NOMI; therefore, we performed a right-sided hemicolectomy on Day 27. Nonocclusive mesenteric ischemia should be considered during the differential diagnosis of intestinal complications after chemotherapy, even in pediatric and adolescent patients. |
| first_indexed | 2024-12-20T22:12:36Z |
| format | Article |
| id | doaj.art-b8dbae6b881b40a49834d2d9b61a3051 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-20T22:12:36Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-b8dbae6b881b40a49834d2d9b61a30512022-12-21T19:25:08ZengElsevierPediatrics and Neonatology1875-95722017-02-01581818410.1016/j.pedneo.2014.07.008Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic LeukemiaKoichi Hirabayashi0Mitsuho Takatsuki1Mitsuo Motobayashi2Takashi Kurata3Shoji Saito4Tomonari Shigemura5Yozo Nakazawa6Kazuo Sakashita7Satoshi Ishizone8Hiroyoshi Ota9Kenichi Koike10Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanFirst Department of Surgery, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Biomedical Sciences, School of Health Sciences, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanNonocclusive mesenteric ischemia (NOMI) is induced by intestinal vasospasm without thromboembolic occlusion and is associated with high morbidity and mortality. The estimated overall incidence of autopsy-verified fatal NOMI is 2.0 cases/100,000 person-years; however, no pediatric or adolescent cases have yet been reported. An 18-year-old female was diagnosed with B-cell precursor acute lymphoblastic leukemia at the age of 10 years. Our patient received three allogeneic hematopoietic stem cell transplantations but experienced hematological relapse after each. She received combination therapy of prednisolone, L-asparaginase, vincristine, and bortezomib after the third relapse. On Day 16 after the initiation of chemotherapy, she developed NOMI; therefore, we performed a right-sided hemicolectomy on Day 27. Nonocclusive mesenteric ischemia should be considered during the differential diagnosis of intestinal complications after chemotherapy, even in pediatric and adolescent patients.http://www.sciencedirect.com/science/article/pii/S187595721400165Xacute lymphoblastic leukemiaadolescentallogeneic hematopoietic stem cell transplantationchemotherapynonocclusive mesenteric ischemia |
| spellingShingle | Koichi Hirabayashi Mitsuho Takatsuki Mitsuo Motobayashi Takashi Kurata Shoji Saito Tomonari Shigemura Yozo Nakazawa Kazuo Sakashita Satoshi Ishizone Hiroyoshi Ota Kenichi Koike Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia Pediatrics and Neonatology acute lymphoblastic leukemia adolescent allogeneic hematopoietic stem cell transplantation chemotherapy nonocclusive mesenteric ischemia |
| title | Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia |
| title_full | Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia |
| title_fullStr | Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia |
| title_short | Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia |
| title_sort | nonocclusive mesenteric ischemia after chemotherapy in an adolescent patient with a history of three allogeneic hematopoietic stem cell transplantations for acute lymphoblastic leukemia |
| topic | acute lymphoblastic leukemia adolescent allogeneic hematopoietic stem cell transplantation chemotherapy nonocclusive mesenteric ischemia |
| url | http://www.sciencedirect.com/science/article/pii/S187595721400165X |
| work_keys_str_mv | AT koichihirabayashi nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT mitsuhotakatsuki nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT mitsuomotobayashi nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT takashikurata nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT shojisaito nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT tomonarishigemura nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT yozonakazawa nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT kazuosakashita nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT satoshiishizone nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT hiroyoshiota nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia AT kenichikoike nonocclusivemesentericischemiaafterchemotherapyinanadolescentpatientwithahistoryofthreeallogeneichematopoieticstemcelltransplantationsforacutelymphoblasticleukemia |