DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILURE
We have practiced courses of treatment with dipyridamol (Curantil, Berlin-Chemie), 25 to 225 mg daily, 1-3 months long, in 55 patients with congestive heart failure NYHA III-IV class in conjuction with baseline treatment with ACE inhibitors, prolonged nitrates and diuretics. Treatment efficacy was c...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2001-02-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2171 |
| _version_ | 1797857374096064512 |
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| author | M. P. Savenkov M. V. Borshevskaya S. N. Ivanov T. V. Belkina V. I. Buvaltsev M. N. Palkin |
| author_facet | M. P. Savenkov M. V. Borshevskaya S. N. Ivanov T. V. Belkina V. I. Buvaltsev M. N. Palkin |
| author_sort | M. P. Savenkov |
| collection | DOAJ |
| description | We have practiced courses of treatment with dipyridamol (Curantil, Berlin-Chemie), 25 to 225 mg daily, 1-3 months long, in 55 patients with congestive heart failure NYHA III-IV class in conjuction with baseline treatment with ACE inhibitors, prolonged nitrates and diuretics. Treatment efficacy was controlled by thromboelastography, ADP-induced platelet aggregation and bifunctional daily BP and ECG monitoring. A dose-dependent and modulating antiaggregating effect of dipyridamol has been shown in the study. The usage of 225 mg Curantil daily (75 mg 3 times a day) resulted in an antiaggregating action in the first day, however, it was characterized by a higher risk of hypotension with concomitant baseline vasodilating therapy. Considerable antiaggregating effect of 75 mg Curnatil daily (25 mg 3 times a day) and 50-25 mg daily developed by the end of the first and, respectively, second week of treatment; the risk of arterial hypotension was non-significant. We conclude that for long-term prevention in patients with CHF administration of Curantil 75-25 mg daily is preferable. Determining individual sensitivity to the chosen dose (by BP dynamics) is rational before initiating the treatment. |
| first_indexed | 2024-04-09T20:55:44Z |
| format | Article |
| id | doaj.art-b8dc7dca4c054ecfb4df2fb65afa7354 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:55:44Z |
| publishDate | 2001-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-b8dc7dca4c054ecfb4df2fb65afa73542023-03-29T21:23:08Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202001-02-010146511923DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILUREM. P. Savenkov0M. V. Borshevskaya1S. N. Ivanov2T. V. Belkina3V. I. Buvaltsev4M. N. Palkin5Российский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетРоссийский государственный медицинский университетWe have practiced courses of treatment with dipyridamol (Curantil, Berlin-Chemie), 25 to 225 mg daily, 1-3 months long, in 55 patients with congestive heart failure NYHA III-IV class in conjuction with baseline treatment with ACE inhibitors, prolonged nitrates and diuretics. Treatment efficacy was controlled by thromboelastography, ADP-induced platelet aggregation and bifunctional daily BP and ECG monitoring. A dose-dependent and modulating antiaggregating effect of dipyridamol has been shown in the study. The usage of 225 mg Curantil daily (75 mg 3 times a day) resulted in an antiaggregating action in the first day, however, it was characterized by a higher risk of hypotension with concomitant baseline vasodilating therapy. Considerable antiaggregating effect of 75 mg Curnatil daily (25 mg 3 times a day) and 50-25 mg daily developed by the end of the first and, respectively, second week of treatment; the risk of arterial hypotension was non-significant. We conclude that for long-term prevention in patients with CHF administration of Curantil 75-25 mg daily is preferable. Determining individual sensitivity to the chosen dose (by BP dynamics) is rational before initiating the treatment.https://russjcardiol.elpub.ru/jour/article/view/2171stable heart failuredipyridamolprevention |
| spellingShingle | M. P. Savenkov M. V. Borshevskaya S. N. Ivanov T. V. Belkina V. I. Buvaltsev M. N. Palkin DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILURE Российский кардиологический журнал stable heart failure dipyridamol prevention |
| title | DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILURE |
| title_full | DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILURE |
| title_fullStr | DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILURE |
| title_full_unstemmed | DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILURE |
| title_short | DOSE-DEPENDENT EFFECTS OF DIPYRIDAMOLE IN PATIENTS WITH CONGESTIVE HEART FAILURE |
| title_sort | dose dependent effects of dipyridamole in patients with congestive heart failure |
| topic | stable heart failure dipyridamol prevention |
| url | https://russjcardiol.elpub.ru/jour/article/view/2171 |
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