Simultaneous silencing of VEGF and KSP by siRNA cocktail inhibits proliferation and induces apoptosis of hepatocellular carcinoma Hep3B cells

Simultaneous silencing of VEGF and KSP by siRNA cocktail inhibits proliferation and induces apoptosis of hepatocellular carcinoma Hep3B cells

BACKGROUND: Vascular endothelial growth factor (VEGF) is involved in the growth of new blood vessels that feed tumors and kinesin spindle protein (KSP) plays a critical role in mitosis involving in cell proliferation. Simultaneous silencing of VEGF and KSP, an attractive and viable approach in cance...

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Bibliographic Details
Main Authors: Chung Chinh Doan, Long Thanh Le, Son Nghia Hoang, Si Minh Do, Dong Van Le
Format: Article
Language:English
Published: BMC 2014-01-01
Series:Biological Research
Subjects:
Vascular endothelial cell growth factor (VEGF)
Kinesin spindle protein (KSP)
siRNA cocktail
Proliferation
Apoptosis
Hepatocellular carcinoma
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100064&lng=en&tlng=en

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100064&lng=en&tlng=en

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