Stress Erythropoiesis is a Key Inflammatory Response
Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow to produce erythrocytes, there are times when it...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/3/634 |
| _version_ | 1797711878798966784 |
|---|---|
| author | Robert F. Paulson Baiye Ruan Siyang Hao Yuanting Chen |
| author_facet | Robert F. Paulson Baiye Ruan Siyang Hao Yuanting Chen |
| author_sort | Robert F. Paulson |
| collection | DOAJ |
| description | Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow to produce erythrocytes, there are times when it is unable to keep pace with erythroid demand. At these times stress erythropoiesis predominates. Stress erythropoiesis generates a large bolus of new erythrocytes to maintain homeostasis until steady state erythropoiesis can resume. In this review, we outline the mechanistic differences between stress erythropoiesis and steady state erythropoiesis and show that their responses to inflammation are complementary. We propose a new hypothesis that stress erythropoiesis is induced by inflammation and plays a key role in maintaining erythroid homeostasis during inflammatory responses. |
| first_indexed | 2024-03-12T07:12:29Z |
| format | Article |
| id | doaj.art-b8e0230645cd48d0bf219a19dfbe70d7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:12:29Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b8e0230645cd48d0bf219a19dfbe70d72023-09-02T23:00:02ZengMDPI AGCells2073-44092020-03-019363410.3390/cells9030634cells9030634Stress Erythropoiesis is a Key Inflammatory ResponseRobert F. Paulson0Baiye Ruan1Siyang Hao2Yuanting Chen3Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease at Penn State University, University Park, PA 16802, USADepartment of Veterinary and Biomedical Sciences, Pathobiology Graduate Program at Penn State University, University Park, PA 16802, USADepartment of Veterinary and Biomedical Sciences, Graduate Program in Molecular, Cellular and Integrative Biosciences at Penn State University, University Park, PA 16802, USADepartment of Veterinary and Biomedical Sciences, Graduate Program in Molecular, Cellular and Integrative Biosciences at Penn State University, University Park, PA 16802, USABone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow to produce erythrocytes, there are times when it is unable to keep pace with erythroid demand. At these times stress erythropoiesis predominates. Stress erythropoiesis generates a large bolus of new erythrocytes to maintain homeostasis until steady state erythropoiesis can resume. In this review, we outline the mechanistic differences between stress erythropoiesis and steady state erythropoiesis and show that their responses to inflammation are complementary. We propose a new hypothesis that stress erythropoiesis is induced by inflammation and plays a key role in maintaining erythroid homeostasis during inflammatory responses.https://www.mdpi.com/2073-4409/9/3/634stress erythropoiesiserythroblastic islandspro-inflammatory cytokineserythrophagocytosisanemia of inflammation |
| spellingShingle | Robert F. Paulson Baiye Ruan Siyang Hao Yuanting Chen Stress Erythropoiesis is a Key Inflammatory Response Cells stress erythropoiesis erythroblastic islands pro-inflammatory cytokines erythrophagocytosis anemia of inflammation |
| title | Stress Erythropoiesis is a Key Inflammatory Response |
| title_full | Stress Erythropoiesis is a Key Inflammatory Response |
| title_fullStr | Stress Erythropoiesis is a Key Inflammatory Response |
| title_full_unstemmed | Stress Erythropoiesis is a Key Inflammatory Response |
| title_short | Stress Erythropoiesis is a Key Inflammatory Response |
| title_sort | stress erythropoiesis is a key inflammatory response |
| topic | stress erythropoiesis erythroblastic islands pro-inflammatory cytokines erythrophagocytosis anemia of inflammation |
| url | https://www.mdpi.com/2073-4409/9/3/634 |
| work_keys_str_mv | AT robertfpaulson stresserythropoiesisisakeyinflammatoryresponse AT baiyeruan stresserythropoiesisisakeyinflammatoryresponse AT siyanghao stresserythropoiesisisakeyinflammatoryresponse AT yuantingchen stresserythropoiesisisakeyinflammatoryresponse |