Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in India
Introduction Robust data are available for C-reactive protein (CRP) in bacterial infection, and it can be used in this coronavirus disease 2019 (COVID-19) pneumonia pandemic for initial assessment before planning of treatment in indoor settings in comparison with other inflammatory markers and compu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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General Organization of Teaching Hospitals and Institutes
2022-01-01
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| Series: | Journal of Medicine in Scientific Research |
| Subjects: | |
| Online Access: | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2022;volume=5;issue=4;spage=430;epage=436;aulast=Patil |
| _version_ | 1827295520096256000 |
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| author | Shital Patil Utreshwar Dhumal Manojkumar Bhadake |
| author_facet | Shital Patil Utreshwar Dhumal Manojkumar Bhadake |
| author_sort | Shital Patil |
| collection | DOAJ |
| description | Introduction
Robust data are available for C-reactive protein (CRP) in bacterial infection, and it can be used in this coronavirus disease 2019 (COVID-19) pneumonia pandemic for initial assessment before planning of treatment in indoor settings in comparison with other inflammatory markers and computed tomography (CT) severity.
Materials and methods
A prospective, observational, follow up study was conducted that included 1000 COVID 19 cases confirmed with RT PCR. All cases were assessed with lung involvement documented and categorized based on high resolution computed tomography (HRCT) thorax, oxygen saturation, and inflammatory markers such as CRP at the entry point and follow up. Age, sex, comorbidities, use of BIPAP/NIV (Bi-level positive airway pressure/Non-invasive ventilation), and outcomes such as with or without lung fibrosis as per HRCT severity were key observations. Statistical analysis was done using χ2 test.
Results
Age (<50 and >50 years) and sex (male versus female) had a significant association with CRP in predicting severity (P < 0.00001 and P < 0.010, respectively). CT severity score at the entry point with CRP level had a significant correlation (P < 0.00001). CRP level had a significant association with duration of illness (P < 0.00001). Comorbidities had a significant association with CRP level (P < 0.00001). CRP level had a significant association with oxygen saturation (P < 0.00001). BIPAP/NIV requirement during hospitalization had a significant association with CRP level (P < 0.00001). Timing of BIPAP/NIV requirement had a significant association with CRP level. (P < 0.00001). Follow-up CRP titer during hospitalization as compared with the entry point normal and abnormal CRP levels showed a significant association in post-COVID lung fibrosis (P < 0.00001).
Conclusion
CRP is an easily available and universally acceptable inflammatory marker and documented to play a very crucial role in predicting timings of interventions and post-COVID lung fibrosis. |
| first_indexed | 2024-04-24T14:21:49Z |
| format | Article |
| id | doaj.art-b8e07cb840434e50a5c766b8152dd0a6 |
| institution | Directory Open Access Journal |
| issn | 2537-091X 2537-0928 |
| language | English |
| last_indexed | 2024-04-24T14:21:49Z |
| publishDate | 2022-01-01 |
| publisher | General Organization of Teaching Hospitals and Institutes |
| record_format | Article |
| series | Journal of Medicine in Scientific Research |
| spelling | doaj.art-b8e07cb840434e50a5c766b8152dd0a62024-04-03T06:40:01ZengGeneral Organization of Teaching Hospitals and InstitutesJournal of Medicine in Scientific Research2537-091X2537-09282022-01-015443043610.4103/jmisr.jmisr_62_22Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in IndiaShital PatilUtreshwar DhumalManojkumar BhadakeIntroduction Robust data are available for C-reactive protein (CRP) in bacterial infection, and it can be used in this coronavirus disease 2019 (COVID-19) pneumonia pandemic for initial assessment before planning of treatment in indoor settings in comparison with other inflammatory markers and computed tomography (CT) severity. Materials and methods A prospective, observational, follow up study was conducted that included 1000 COVID 19 cases confirmed with RT PCR. All cases were assessed with lung involvement documented and categorized based on high resolution computed tomography (HRCT) thorax, oxygen saturation, and inflammatory markers such as CRP at the entry point and follow up. Age, sex, comorbidities, use of BIPAP/NIV (Bi-level positive airway pressure/Non-invasive ventilation), and outcomes such as with or without lung fibrosis as per HRCT severity were key observations. Statistical analysis was done using χ2 test. Results Age (<50 and >50 years) and sex (male versus female) had a significant association with CRP in predicting severity (P < 0.00001 and P < 0.010, respectively). CT severity score at the entry point with CRP level had a significant correlation (P < 0.00001). CRP level had a significant association with duration of illness (P < 0.00001). Comorbidities had a significant association with CRP level (P < 0.00001). CRP level had a significant association with oxygen saturation (P < 0.00001). BIPAP/NIV requirement during hospitalization had a significant association with CRP level (P < 0.00001). Timing of BIPAP/NIV requirement had a significant association with CRP level. (P < 0.00001). Follow-up CRP titer during hospitalization as compared with the entry point normal and abnormal CRP levels showed a significant association in post-COVID lung fibrosis (P < 0.00001). Conclusion CRP is an easily available and universally acceptable inflammatory marker and documented to play a very crucial role in predicting timings of interventions and post-COVID lung fibrosis.http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2022;volume=5;issue=4;spage=430;epage=436;aulast=Patilcovid-19 pneumoniacrpinflammatory markeroxygen saturation |
| spellingShingle | Shital Patil Utreshwar Dhumal Manojkumar Bhadake Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in India Journal of Medicine in Scientific Research covid-19 pneumonia crp inflammatory marker oxygen saturation |
| title | Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in India |
| title_full | Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in India |
| title_fullStr | Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in India |
| title_full_unstemmed | Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in India |
| title_short | Role of CRP in COVID-19 pneumonia: A single-center experience of 1000 cases in a tertiary care setting in India |
| title_sort | role of crp in covid 19 pneumonia a single center experience of 1000 cases in a tertiary care setting in india |
| topic | covid-19 pneumonia crp inflammatory marker oxygen saturation |
| url | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2022;volume=5;issue=4;spage=430;epage=436;aulast=Patil |
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