Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats
Background: Omentin-1 plays an important role in insulin function. Despite numerous studies, the effect of interval training on this adipokine is still vague. This study aimed to elucidate the effect of high-intensity interval training (HIIT) on serum glucose, insulin, insulin resistance (IR), oment...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Golestan University of Medical Sciences
2023-10-01
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| Series: | Medical Laboratory Journal |
| Subjects: | |
| Online Access: | http://mlj.goums.ac.ir/article-1-1173-en.pdf |
| _version_ | 1797301278566514688 |
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| author | Nasrin Ramezani Mahshid Dezhan Saide Saadaat Khalili Nader Shakeri Kayvan Khoramipour |
| author_facet | Nasrin Ramezani Mahshid Dezhan Saide Saadaat Khalili Nader Shakeri Kayvan Khoramipour |
| author_sort | Nasrin Ramezani |
| collection | DOAJ |
| description | Background: Omentin-1 plays an important role in insulin function. Despite numerous studies, the effect of interval training on this adipokine is still vague. This study aimed to elucidate the effect of high-intensity interval training (HIIT) on serum glucose, insulin, insulin resistance (IR), omentin-1 serum levels, and gene expression in the visceral adipose tissue in type 2 diabetic (T2D) rats.
Methods: In an experimental study, 20 male rats (8-10 weeks, weight: 250-270 g) were randomly divided into 2 groups: diabetic control (N=10) and diabetic training (N=10). The training protocol was 30 minutes of HIIT (1-min run, 2-min rest) performed 5 days a week for 4 weeks. Fasting blood glucose, insulin resistance, omentin-1 serum level, and gene expression were measured in the visceral fat 48 hours after the last exercise for both groups.
Results: The HIIT resulted in lower serum glucose and insulin resistance (P = 0.001), higher serum omentin-1 levels (P = 0.001), and higher visceral fat gene expression (P = 0.004) in the training group compared to the control group.
Conclusion: Lower serum glucose and insulin resistance and higher omentin-1 serum levels and gene expression in the training group can prove the effectiveness of HIIT training in T2D, although further research is required. |
| first_indexed | 2024-03-07T23:20:14Z |
| format | Article |
| id | doaj.art-b8e0d57e90164d23b66cdd723dc6c3ca |
| institution | Directory Open Access Journal |
| issn | 2538-4449 |
| language | English |
| last_indexed | 2024-03-07T23:20:14Z |
| publishDate | 2023-10-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj.art-b8e0d57e90164d23b66cdd723dc6c3ca2024-02-21T07:03:44ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492023-10-011752022Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic ratsNasrin Ramezani0Mahshid Dezhan1Saide Saadaat Khalili2Nader Shakeri3Kayvan Khoramipour4 Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, University of Tehran, Tehran, Iran Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Center Tehran Branch, Tehran, Iran Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Saveh Branch, Saveh, Iran Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Olum Tahghighat Branch, Tehran, Iran. Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, University of Tehran, Tehran, Iran Background: Omentin-1 plays an important role in insulin function. Despite numerous studies, the effect of interval training on this adipokine is still vague. This study aimed to elucidate the effect of high-intensity interval training (HIIT) on serum glucose, insulin, insulin resistance (IR), omentin-1 serum levels, and gene expression in the visceral adipose tissue in type 2 diabetic (T2D) rats. Methods: In an experimental study, 20 male rats (8-10 weeks, weight: 250-270 g) were randomly divided into 2 groups: diabetic control (N=10) and diabetic training (N=10). The training protocol was 30 minutes of HIIT (1-min run, 2-min rest) performed 5 days a week for 4 weeks. Fasting blood glucose, insulin resistance, omentin-1 serum level, and gene expression were measured in the visceral fat 48 hours after the last exercise for both groups. Results: The HIIT resulted in lower serum glucose and insulin resistance (P = 0.001), higher serum omentin-1 levels (P = 0.001), and higher visceral fat gene expression (P = 0.004) in the training group compared to the control group. Conclusion: Lower serum glucose and insulin resistance and higher omentin-1 serum levels and gene expression in the training group can prove the effectiveness of HIIT training in T2D, although further research is required.http://mlj.goums.ac.ir/article-1-1173-en.pdfhigh-intensity interval traininginsulin resistancediabetes mellitustype 2 |
| spellingShingle | Nasrin Ramezani Mahshid Dezhan Saide Saadaat Khalili Nader Shakeri Kayvan Khoramipour Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats Medical Laboratory Journal high-intensity interval training insulin resistance diabetes mellitus type 2 |
| title | Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats |
| title_full | Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats |
| title_fullStr | Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats |
| title_full_unstemmed | Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats |
| title_short | Effect of high-intensity interval training on omentin-1 serum levels, gene expression, and insulin resistance in type 2 diabetic rats |
| title_sort | effect of high intensity interval training on omentin 1 serum levels gene expression and insulin resistance in type 2 diabetic rats |
| topic | high-intensity interval training insulin resistance diabetes mellitus type 2 |
| url | http://mlj.goums.ac.ir/article-1-1173-en.pdf |
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