Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71

Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71

Novel insights on proteins involved in Alzheimer’s disease (AD) are needed. Since multiple cell types and matrix components are altered in AD, bulk analysis of brain tissue maybe difficult to interpret. In the current study, we isolated pyramidal cells from the cornu ammonis 1 (CA1) region of the hi...

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Bibliographic Details
Main Authors: Anna Sandebring-Matton, Michael Axenhus, Nenad Bogdanovic, Bengt Winblad, Sophia Schedin-Weiss, Per Nilsson, Lars O. Tjernberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
14-3-3-γ
creatine kinase B
heat shock cognate 71
laser capture microscopy
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.735334/full

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