The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2023-11-01
|
| Series: | ACS Bio & Med Chem Au |
| Online Access: | https://doi.org/10.1021/acsbiomedchemau.3c00039 |
| _version_ | 1797384973323337728 |
|---|---|
| author | Elena Arutyunova Alexandr Belovodskiy Pu Chen Muhammad Bashir Khan Michael Joyce Holly Saffran Jimmy Lu Zoe Turner Bing Bai Tess Lamer Howard S. Young John C. Vederas D. Lorne Tyrrell M. Joanne Lemieux James A. Nieman |
| author_facet | Elena Arutyunova Alexandr Belovodskiy Pu Chen Muhammad Bashir Khan Michael Joyce Holly Saffran Jimmy Lu Zoe Turner Bing Bai Tess Lamer Howard S. Young John C. Vederas D. Lorne Tyrrell M. Joanne Lemieux James A. Nieman |
| author_sort | Elena Arutyunova |
| collection | DOAJ |
| first_indexed | 2024-03-08T21:47:26Z |
| format | Article |
| id | doaj.art-b8e37dea5f004761a5ac48cc97ba66e2 |
| institution | Directory Open Access Journal |
| issn | 2694-2437 |
| language | English |
| last_indexed | 2024-03-08T21:47:26Z |
| publishDate | 2023-11-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Bio & Med Chem Au |
| spelling | doaj.art-b8e37dea5f004761a5ac48cc97ba66e22023-12-20T08:10:16ZengAmerican Chemical SocietyACS Bio & Med Chem Au2694-24372023-11-013652854110.1021/acsbiomedchemau.3c00039The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative MetabolismElena Arutyunova0Alexandr Belovodskiy1Pu Chen2Muhammad Bashir Khan3Michael Joyce4Holly Saffran5Jimmy Lu6Zoe Turner7Bing Bai8Tess Lamer9Howard S. Young10John C. Vederas11D. Lorne Tyrrell12M. Joanne Lemieux13James A. Nieman14Department of Biochemistry, University of Alberta, Edmonton, AB, CanadaLi Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB, CanadaLi Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, CanadaLi Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB, CanadaLi Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, CanadaDepartment of Chemistry, University of Alberta, Edmonton, AB, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB, CanadaDepartment of Chemistry, University of Alberta, Edmonton, AB, CanadaLi Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, CanadaDepartment of Biochemistry, University of Alberta, Edmonton, AB, CanadaLi Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canadahttps://doi.org/10.1021/acsbiomedchemau.3c00039 |
| spellingShingle | Elena Arutyunova Alexandr Belovodskiy Pu Chen Muhammad Bashir Khan Michael Joyce Holly Saffran Jimmy Lu Zoe Turner Bing Bai Tess Lamer Howard S. Young John C. Vederas D. Lorne Tyrrell M. Joanne Lemieux James A. Nieman The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism ACS Bio & Med Chem Au |
| title | The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism |
| title_full | The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism |
| title_fullStr | The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism |
| title_full_unstemmed | The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism |
| title_short | The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism |
| title_sort | effect of deuteration and homologation of the lactam ring of nirmatrelvir on its biochemical properties and oxidative metabolism |
| url | https://doi.org/10.1021/acsbiomedchemau.3c00039 |
| work_keys_str_mv | AT elenaarutyunova theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT alexandrbelovodskiy theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT puchen theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT muhammadbashirkhan theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT michaeljoyce theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT hollysaffran theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT jimmylu theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT zoeturner theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT bingbai theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT tesslamer theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT howardsyoung theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT johncvederas theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT dlornetyrrell theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT mjoannelemieux theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT jamesanieman theeffectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT elenaarutyunova effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT alexandrbelovodskiy effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT puchen effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT muhammadbashirkhan effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT michaeljoyce effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT hollysaffran effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT jimmylu effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT zoeturner effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT bingbai effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT tesslamer effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT howardsyoung effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT johncvederas effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT dlornetyrrell effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT mjoannelemieux effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism AT jamesanieman effectofdeuterationandhomologationofthelactamringofnirmatrelvironitsbiochemicalpropertiesandoxidativemetabolism |