Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study
ObjectivesWe aim to investigate the functional profiles of perilesional gray matter (GM) in epileptic patients with focal cortical dysplasia (FCD) and to correlate these profiles with FCD II subtypes, surgical outcomes, and different antiseizure medications (ASMs) treatment response patterns.Methods...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1286302/full |
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| author | Bo Jin Jiahui Xu Chao Wang Shan Wang Hong Li Cong Chen Linqi Ye Chenmin He Hui Cheng Lisan Zhang Shuang Wang Jin Wang Thandar Aung |
| author_facet | Bo Jin Jiahui Xu Chao Wang Shan Wang Hong Li Cong Chen Linqi Ye Chenmin He Hui Cheng Lisan Zhang Shuang Wang Jin Wang Thandar Aung |
| author_sort | Bo Jin |
| collection | DOAJ |
| description | ObjectivesWe aim to investigate the functional profiles of perilesional gray matter (GM) in epileptic patients with focal cortical dysplasia (FCD) and to correlate these profiles with FCD II subtypes, surgical outcomes, and different antiseizure medications (ASMs) treatment response patterns.MethodsNine patients with drug-responsive epilepsy and 30 patients with drug-resistant epilepsy (11 were histologically confirmed FCD type IIa, 19 were FCD type IIb) were included. Individual-specific perilesional GM and contralateral homotopic GM layer masks were generated. These masks underwent a two-voxel (2 mm) dilation from the FCD lesion and contralateral homotopic region, resulting in 10 GM layers (20 mm). Layer 1, the innermost, progressed to Layer 10, the outermost. Amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) analyses were conducted to assess the functional characteristics of ipsilateral perilesional GM and contralateral homotopic GM.ResultsCompared to the contralateral homotopic GM, a significant reduction of ALFF was detected at ipsilateral perilesional GM layer 1 to 6 in FCD type IIa (after Bonferroni correction p < 0.005, paired t-test), whereas a significant decrease was observed at ipsilateral perilesional GM layer 1 to 2 in FCD type IIb (after Bonferroni correction p < 0.005, paired t-test). Additionally, a significant decrease of the ReHo was detected at ipsilateral perilesional GM layer 1 compared to the CHRs in FCD type IIb. Notably, complete resection of functional perilesional GM alterations did not correlate with surgical outcomes. Compared to the contralateral homotopic GM, a decreased ALFF in the ipsilateral perilesional GM layer was detected in drug-responsive patients, whereas decreased ALFF in the ipsilateral perilesional GM layer 1–6 and decreased ReHo at ipsilateral perilesional GM layer 1 were observed in drug-resistant patients (after Bonferroni correction p < 0.005, paired t-test).ConclusionOur findings indicate distinct functional profiles of perilesional GM based on FCD histological subtypes and ASMs’ response patterns. Importantly, our study illustrates that the identified functional alterations in perilesional GM may not provide sufficient evidence to determine the epileptogenic boundary required for surgical resection. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-08T12:30:30Z |
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| spelling | doaj.art-b8e40650a4804900ac49a24b054068752024-01-22T04:25:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-01-011810.3389/fnins.2024.12863021286302Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI studyBo Jin0Jiahui Xu1Chao Wang2Shan Wang3Hong Li4Cong Chen5Linqi Ye6Chenmin He7Hui Cheng8Lisan Zhang9Shuang Wang10Jin Wang11Thandar Aung12Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Epilepsy Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesObjectivesWe aim to investigate the functional profiles of perilesional gray matter (GM) in epileptic patients with focal cortical dysplasia (FCD) and to correlate these profiles with FCD II subtypes, surgical outcomes, and different antiseizure medications (ASMs) treatment response patterns.MethodsNine patients with drug-responsive epilepsy and 30 patients with drug-resistant epilepsy (11 were histologically confirmed FCD type IIa, 19 were FCD type IIb) were included. Individual-specific perilesional GM and contralateral homotopic GM layer masks were generated. These masks underwent a two-voxel (2 mm) dilation from the FCD lesion and contralateral homotopic region, resulting in 10 GM layers (20 mm). Layer 1, the innermost, progressed to Layer 10, the outermost. Amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) analyses were conducted to assess the functional characteristics of ipsilateral perilesional GM and contralateral homotopic GM.ResultsCompared to the contralateral homotopic GM, a significant reduction of ALFF was detected at ipsilateral perilesional GM layer 1 to 6 in FCD type IIa (after Bonferroni correction p < 0.005, paired t-test), whereas a significant decrease was observed at ipsilateral perilesional GM layer 1 to 2 in FCD type IIb (after Bonferroni correction p < 0.005, paired t-test). Additionally, a significant decrease of the ReHo was detected at ipsilateral perilesional GM layer 1 compared to the CHRs in FCD type IIb. Notably, complete resection of functional perilesional GM alterations did not correlate with surgical outcomes. Compared to the contralateral homotopic GM, a decreased ALFF in the ipsilateral perilesional GM layer was detected in drug-responsive patients, whereas decreased ALFF in the ipsilateral perilesional GM layer 1–6 and decreased ReHo at ipsilateral perilesional GM layer 1 were observed in drug-resistant patients (after Bonferroni correction p < 0.005, paired t-test).ConclusionOur findings indicate distinct functional profiles of perilesional GM based on FCD histological subtypes and ASMs’ response patterns. Importantly, our study illustrates that the identified functional alterations in perilesional GM may not provide sufficient evidence to determine the epileptogenic boundary required for surgical resection.https://www.frontiersin.org/articles/10.3389/fnins.2024.1286302/fullepilepsyfocal cortical dysplasiaantiseizure medicationgray matterfunctional MRI |
| spellingShingle | Bo Jin Jiahui Xu Chao Wang Shan Wang Hong Li Cong Chen Linqi Ye Chenmin He Hui Cheng Lisan Zhang Shuang Wang Jin Wang Thandar Aung Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study Frontiers in Neuroscience epilepsy focal cortical dysplasia antiseizure medication gray matter functional MRI |
| title | Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study |
| title_full | Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study |
| title_fullStr | Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study |
| title_full_unstemmed | Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study |
| title_short | Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study |
| title_sort | functional profile of perilesional gray matter in focal cortical dysplasia an fmri study |
| topic | epilepsy focal cortical dysplasia antiseizure medication gray matter functional MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1286302/full |
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