Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis
Chronic communication impairment is common after stroke, and conventional speech and language therapy (SLT) strategies have limited effectiveness in post-stroke aphasia. Neurorehabilitation with non-invasive brain stimulation techniques (NIBS) ‒ particularly repetitive transcranial magnetic stimulat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00236/full |
| _version_ | 1819145341863198720 |
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| author | Begonya eOtal Manuel C Olma Agnes eFlöel Agnes eFlöel Ian eWellwood |
| author_facet | Begonya eOtal Manuel C Olma Agnes eFlöel Agnes eFlöel Ian eWellwood |
| author_sort | Begonya eOtal |
| collection | DOAJ |
| description | Chronic communication impairment is common after stroke, and conventional speech and language therapy (SLT) strategies have limited effectiveness in post-stroke aphasia. Neurorehabilitation with non-invasive brain stimulation techniques (NIBS) ‒ particularly repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) ‒ may enhance the effects of SLT in selected patients. Applying inhibitory NIBS to specific homologous language regions may induce neural reorganization and reduce interhemispheric competition. This mini review highlights randomized controlled trials (RCTs) and randomized cross-over trials using low-frequency rTMS or cathodal tDCS over the non-lesioned non-language dominant hemisphere and performs an exploratory meta-analysis of those trials considered combinable. Using a random-effects model, a meta-analysis of nine eligible trials involving 215 participants showed a significant mean effect size of 0.51 (95% CI = 0.24 to 0.79) for the main outcome accuracy of naming in language assessment. No heterogeneity was observed (I2 = 0%). More multicenter RCTs with larger populations and homogenous intervention protocols are required to confirm these and the longer-term effects. |
| first_indexed | 2024-12-22T12:56:30Z |
| format | Article |
| id | doaj.art-b8e6ba1ee87c46a29a5d9a9e1fe4b6b1 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T12:56:30Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-b8e6ba1ee87c46a29a5d9a9e1fe4b6b12022-12-21T18:25:06ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-04-01910.3389/fnhum.2015.00236133103Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysisBegonya eOtal0Manuel C Olma1Agnes eFlöel2Agnes eFlöel3Ian eWellwood4Center for Stroke Research Berlin, Charité University MedicineCenter for Stroke Research Berlin, Charité University MedicineCenter for Stroke Research Berlin, Charité University MedicineNeuroCure Clinical Research Center, Charité University MedicineCenter for Stroke Research Berlin, Charité University MedicineChronic communication impairment is common after stroke, and conventional speech and language therapy (SLT) strategies have limited effectiveness in post-stroke aphasia. Neurorehabilitation with non-invasive brain stimulation techniques (NIBS) ‒ particularly repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) ‒ may enhance the effects of SLT in selected patients. Applying inhibitory NIBS to specific homologous language regions may induce neural reorganization and reduce interhemispheric competition. This mini review highlights randomized controlled trials (RCTs) and randomized cross-over trials using low-frequency rTMS or cathodal tDCS over the non-lesioned non-language dominant hemisphere and performs an exploratory meta-analysis of those trials considered combinable. Using a random-effects model, a meta-analysis of nine eligible trials involving 215 participants showed a significant mean effect size of 0.51 (95% CI = 0.24 to 0.79) for the main outcome accuracy of naming in language assessment. No heterogeneity was observed (I2 = 0%). More multicenter RCTs with larger populations and homogenous intervention protocols are required to confirm these and the longer-term effects.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00236/fullAphasiaStrokeNeurorehabilitationtDCSTMSrTMS |
| spellingShingle | Begonya eOtal Manuel C Olma Agnes eFlöel Agnes eFlöel Ian eWellwood Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis Frontiers in Human Neuroscience Aphasia Stroke Neurorehabilitation tDCS TMS rTMS |
| title | Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis |
| title_full | Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis |
| title_fullStr | Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis |
| title_full_unstemmed | Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis |
| title_short | Inhibitory non-invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post-stroke aphasia: a meta-analysis |
| title_sort | inhibitory non invasive brain stimulation to homologous language regions as an adjunct to speech and language therapy in post stroke aphasia a meta analysis |
| topic | Aphasia Stroke Neurorehabilitation tDCS TMS rTMS |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00236/full |
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