An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans
Abstract Background Members of the Rosaceae, Solanaceae and Zingiberaceae families which include fruits such as cherries, tomatoes and ginger are known to have health promoting effects. There is growing interest in consuming these “functional foods” as a means to increase health and healthy ageing....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40795-022-00498-8 |
| _version_ | 1798026182732546048 |
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| author | Samantha Hughes Nikki Kolsters David van de Klashorst Emanuel Kreuter Karin Berger Büter |
| author_facet | Samantha Hughes Nikki Kolsters David van de Klashorst Emanuel Kreuter Karin Berger Büter |
| author_sort | Samantha Hughes |
| collection | DOAJ |
| description | Abstract Background Members of the Rosaceae, Solanaceae and Zingiberaceae families which include fruits such as cherries, tomatoes and ginger are known to have health promoting effects. There is growing interest in consuming these “functional foods” as a means to increase health and healthy ageing. However, many studies explore the effect of these foods in isolation, not as a blend of multiple functional foods. Methods In this study, an extract containing the dried berries, fruits, and roots of members of these families was prepared, which we called Bioact®180. The nematode Caenorhabditis elegans was used to evaluate the effects of Bioact®180 on lifespan and health endpoints, including muscle and mitochondria structure and locomotion. Results Exposure to the 1000 µg/mL of Bioact®180 extract, containing 4% total phenols, were healthier, as observed by an increase in mean lifespan with and small but significant increase in maximal lifespan. Nematodes exposed to Bioact®180 displayed better mobility in mid-life stages as well as enhanced mitochondrial morphology, which was more comparable to younger animals, suggesting that these worms are protected to some degree from sarcopenia. Conclusions Together, our findings reveal that Bioact®180, a blend of fruits and roots from Rosaceae, Solanaceae and Zingiberaceae family members has anti-aging effects. Bioact®180 promotes health and lifespan extension in C. elegans, corresponding to functional improvements in mobility. |
| first_indexed | 2024-04-11T18:31:16Z |
| format | Article |
| id | doaj.art-b8e7f17b53664ca184e40844bd0c37d5 |
| institution | Directory Open Access Journal |
| issn | 2055-0928 |
| language | English |
| last_indexed | 2024-04-11T18:31:16Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nutrition |
| spelling | doaj.art-b8e7f17b53664ca184e40844bd0c37d52022-12-22T04:09:26ZengBMCBMC Nutrition2055-09282022-01-018111210.1186/s40795-022-00498-8An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegansSamantha Hughes0Nikki Kolsters1David van de Klashorst2Emanuel Kreuter3Karin Berger Büter4BioCentre, HAN University of Applied SciencesBioCentre, HAN University of Applied SciencesBioCentre, HAN University of Applied SciencesBioactive Botanicals Swiss AGBioactive Botanicals Swiss AGAbstract Background Members of the Rosaceae, Solanaceae and Zingiberaceae families which include fruits such as cherries, tomatoes and ginger are known to have health promoting effects. There is growing interest in consuming these “functional foods” as a means to increase health and healthy ageing. However, many studies explore the effect of these foods in isolation, not as a blend of multiple functional foods. Methods In this study, an extract containing the dried berries, fruits, and roots of members of these families was prepared, which we called Bioact®180. The nematode Caenorhabditis elegans was used to evaluate the effects of Bioact®180 on lifespan and health endpoints, including muscle and mitochondria structure and locomotion. Results Exposure to the 1000 µg/mL of Bioact®180 extract, containing 4% total phenols, were healthier, as observed by an increase in mean lifespan with and small but significant increase in maximal lifespan. Nematodes exposed to Bioact®180 displayed better mobility in mid-life stages as well as enhanced mitochondrial morphology, which was more comparable to younger animals, suggesting that these worms are protected to some degree from sarcopenia. Conclusions Together, our findings reveal that Bioact®180, a blend of fruits and roots from Rosaceae, Solanaceae and Zingiberaceae family members has anti-aging effects. Bioact®180 promotes health and lifespan extension in C. elegans, corresponding to functional improvements in mobility.https://doi.org/10.1186/s40795-022-00498-8C. elegansHealth spanPlant extractSarcopeniaMuscleMitochondria |
| spellingShingle | Samantha Hughes Nikki Kolsters David van de Klashorst Emanuel Kreuter Karin Berger Büter An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans BMC Nutrition C. elegans Health span Plant extract Sarcopenia Muscle Mitochondria |
| title | An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans |
| title_full | An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans |
| title_fullStr | An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans |
| title_full_unstemmed | An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans |
| title_short | An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans |
| title_sort | extract of rosaceae solanaceae and zingiberaceae increases health span and mobility in caenorhabditis elegans |
| topic | C. elegans Health span Plant extract Sarcopenia Muscle Mitochondria |
| url | https://doi.org/10.1186/s40795-022-00498-8 |
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